INT209917

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
leukocytes 1
Msu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 83 99.42 Very High Very High Very High
cytokine 17 99.20 Very High Very High Very High
corticosteroid 4 91.24 High High
cINOD 12 89.92 High High
Arthritis 27 80.96 Quite High
chemokine 6 71.80 Quite High
Inflammatory stimuli 1 58.72 Quite High
anakinra 24 50.00 Quite Low
Pain 9 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 151 100.00 Very High Very High Very High
INFLAMMATION 96 99.42 Very High Very High Very High
Gastrointestinal Disease 1 98.04 Very High Very High Very High
Arthritis 23 80.96 Quite High
Adhesions 2 73.68 Quite High
Death 3 54.92 Quite High
Peritonitis 7 28.00 Quite Low
Foreign Bodies 1 26.04 Quite Low
Disorder Of Lipid Metabolism 1 12.56 Low Low
Pain 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When macrophages were differentiated in vitro, they became less proinflammatory in their response to MSU crystals, even though they retained their capacity for phagocytosis [7].
Localization (response) of MSU in macrophages associated with crystal associated disease
1) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.85 Pain Relevance 0.26
Gouty inflammation is due to monosodium urate (MSU) crystal-induced release of proinflammatory cytokines from leukocytes.
Localization (release) of MSU in leukocytes associated with inflammation, crystal associated disease and cytokine
2) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.96 Pain Relevance 0.40

General Comments

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