INT209918

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.06
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nlrp3)
Nlrp3 (Mus musculus)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 3 98.24 Very High Very High Very High
Inflammation 15 97.12 Very High Very High Very High
chemokine 1 95.24 Very High Very High Very High
cytokine 4 86.84 High High
anakinra 24 71.84 Quite High
Arthritis 23 58.88 Quite High
Pain 7 58.48 Quite High
cINOD 11 40.20 Quite Low
corticosteroid 4 5.00 Very Low Very Low Very Low
diclofenac 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 76 99.80 Very High Very High Very High
INFLAMMATION 22 97.88 Very High Very High Very High
Adhesions 1 90.28 High High
Arthritis 19 58.88 Quite High
Hepatitis 2 49.20 Quite Low
Arthralgia 3 48.08 Quite Low
Diarrhoea 5 25.92 Quite Low
Diabetes Mellitus 4 5.84 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recent finding that MSU crystals induce IL-1 release by activation of the NALP3 inflammasome led us to investigate whether IL-1 blockade could inhibit inflammation provoked by MSU.
Positive_regulation (activation) of NALP3 Positive_regulation (induce) of Localization (release) of IL-1 associated with inflammation and crystal associated disease
1) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 1.06 Pain Relevance 0.40

General Comments

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