INT20992

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 9.04
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
neutrophils 4
LGN 2
sputum 1
blood 1
lens 1
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 7 100.00 Very High Very High Very High
cocaine 8 98.38 Very High Very High Very High
Enkephalin 6 97.28 Very High Very High Very High
Potency 2 92.72 High High
anesthesia 13 88.32 High High
lidocaine 3 81.76 Quite High
Inflammation 108 78.24 Quite High
Central nervous system 88 70.88 Quite High
chemokine 4 70.08 Quite High
local anesthetic 6 64.40 Quite High
Disease Link Frequency Relevance Heat
Adhesions 223 100.00 Very High Very High Very High
Ocular Hypertension 284 99.52 Very High Very High Very High
Coronary Artery Disease 43 99.52 Very High Very High Very High
Optic Nerve Injuries 140 98.76 Very High Very High Very High
Asthma 52 98.32 Very High Very High Very High
Metastasis 15 98.20 Very High Very High Very High
Apoptosis 10 94.84 High High
Hypoxia 7 94.84 High High
Nicotine Addiction 366 94.40 High High
Cancer 126 91.94 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess the effect of opioid peptides on CD11a, CD11b, CD18 and CD16 molecule expression the whole blood samples were incubated with different concentrations of the opioids, then the white cells were labelled with respective PE-conjugated MoAb and evaluated by flow cytometry.
Regulation (effect) of CD18 in blood associated with opioid
1) Confidence 0.37 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0.15 Pain Relevance 0.91
Cocaine and its derivatives blunted responses of neutrophils (cell/cell aggregation, up-regulation of the receptor for C3bi (CR3, CD11b/CD18), generation of superoxide anion (O2-) and degranulation to various stimuli.
Regulation (regulation) of CD18 in neutrophils associated with cocaine
2) Confidence 0.26 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2161879 Disease Relevance 0 Pain Relevance 0.51
Further, loss of OXPHOS genes SLC25A5, ATP6V1B1, B3, V0A4, and NDUFA4 may contribute to the self-sufficiency of the cancer cells with the ability to be less dependent on OXPHOS (2) The loss of tumor suppressor genes PTPRO, TFAP2A, CDKN1C, AIM1 and MT1G as well as other genes that were shown to suppress tumor growth in cancer cell lines but not yet identified as tumor suppressor candidates (RASD1, VDR, EHF, SPP1, ACPP, MT1F and ERBB4) contributes to insensitivity to antigrowth signals; (3) Evasion of apoptosis is mediated through loss of SPP1 and SFRP1, and activation of TUBB, NOL3 and EGLN3. (4) Two groups of genes are likely to be involved in tissue invasion and metastasis: proteolysis genes (PAPPA, PSMB9 and MARCH-1) and genes involved in cell-adhesion and/or regulation of actin cytoskeleton (CNGLN, ITPR2, NPHS1, ITGB2, CLD1, ZAK, WASF2, CD81) and (5) Angiogenesis may be mediated through ALDOA enzyme which is shown to be activated by HIF1 under hypoxic conditions and by increased glycolytic activity (Warburg effect), and which in a feedback loop activates HIF1 (Lu et al. 2002) which then activates several angiogenic factors including VEGF.
Regulation (regulation) of ITGB2 associated with hypoxia, cancer, apoptosis, adhesions and metastasis
3) Confidence 0.17 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.18 Pain Relevance 0
Thus, up-regulation of CD11b/CD18 in primed neutrophils, coupled with endothelial ICAM-1 expression, would be expected to contribute to inappropriate neutrophil adhesion in smokers in cardiovascular, pulmonary, or other environments, with potential ramifications to local tissue integrity.
Regulation (regulation) of CD18 in neutrophils associated with nicotine addiction and adhesions
4) Confidence 0.14 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.99 Pain Relevance 0
Thus, up-regulation of CD11b/CD18 in primed neutrophils, coupled with endothelial ICAM-1 expression, would be expected to contribute to inappropriate neutrophil adhesion in smokers in cardiovascular, pulmonary, or other environments, with potential ramifications to local tissue integrity.
Regulation (regulation) of CD18 in neutrophils associated with nicotine addiction and adhesions
5) Confidence 0.14 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.99 Pain Relevance 0
2-integrins compared to patients with stable CAD [7], [11], while no up-regulation of CD11b/CD18 has been found on neutrophils from patients with stable CAD compared to healthy controls [7], [10], [11].
Regulation (regulation) of CD18 in neutrophils associated with coronary artery disease
6) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.65 Pain Relevance 0.07
To our knowledge the effect of

CVVHD on the important adhesion molecules CD11a, CD11b, CD18 and CD44 has not been investigated before.

Spec (investigated) Regulation (effect) of CD18 associated with adhesions
7) Confidence 0.08 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.07 Pain Relevance 0
High power images of GFAP and MAC-1 immunoreactivity (Figure 1D-I, Figure 2D-I, Figure 3D-I, and Figure 4D-I) were taken using a 100× oil objective lens.
Regulation (immunoreactivity) of MAC-1 in lens
8) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0 Pain Relevance 0
In the OHT animals, GFAP, but not MAC-1, immunoreactivity was elevated in spatial register with the treated eye layers of LGN and V1.
Regulation (immunoreactivity) of MAC-1 in LGN associated with ocular hypertension
9) Confidence 0.04 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2773743 Disease Relevance 1.28 Pain Relevance 0.10
MAC-1 immunoreactivity was at background levels in the LGN (Figure 3C and Figure 5A) and V1 (Figure 4C) of the animals with unilateral OHT.
Regulation (immunoreactivity) of MAC-1 associated with ocular hypertension
10) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.72 Pain Relevance 0
GFAP and MAC-1 immunoreactivities were elevated in spatial register with the treated eye layers of the LGN and V1 in ONT animals.
Regulation (immunoreactivities) of MAC-1 in LGN associated with optic nerve injuries
11) Confidence 0.04 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2773743 Disease Relevance 1.24 Pain Relevance 0.10
The allergen-induced levels of beta-chain mRNA and CCR3 mRNA in sputum-derived cells were inhibited by TPIASM8, but no significant effects on cell surface protein expression of CCR3 and the beta-chain were found.
Neg (no) Regulation (effects) of beta-chain in sputum
12) Confidence 0.01 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.75 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox