INT209922

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B, NOS1) aging (IL1B) cytoplasm (NOS1)
cell-cell signaling (IL1B) extracellular space (IL1B) signal transduction (IL1B)
Anatomy Link Frequency
chondrocytes 2
IL1B (Homo sapiens)
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 65 98.72 Very High Very High Very High
Arthritis 2 50.88 Quite High
Inflammation 16 38.12 Quite Low
metalloproteinase 2 28.72 Quite Low
Inflammatory mediators 5 16.92 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 66 98.72 Very High Very High Very High
Disease 6 90.56 High High
Obesity 2 84.80 Quite High
Arthritis 4 50.88 Quite High
INFLAMMATION 23 38.12 Quite Low
Arthropathy 1 9.00 Low Low
Asthma 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activation inhibits the IL-1-induced expression of inducible nitric oxide synthase, MMP-13, COX-2, and mPGES-1 in chondrocytes [4,11,12].
IL-1 Positive_regulation (induced) of Gene_expression (expression) of nitric oxide synthase in chondrocytes
1) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.41 Pain Relevance 0.12

General Comments

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