INT209923

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.46
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARA) small molecule metabolic process (PPARA) DNA binding (PPARA)
lipid metabolic process (PPARA) cell-cell signaling (IL17A) lipid binding (PPARA)
IL17A (Homo sapiens)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 195 100.00 Very High Very High Very High
Inflammatory mediators 15 93.36 High High
Inflammation 48 86.64 High High
cytokine 12 71.80 Quite High
Multiple sclerosis 3 63.08 Quite High
Inflammatory stimuli 3 60.08 Quite High
metalloproteinase 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 198 100.00 Very High Very High Very High
INFLAMMATION 69 93.36 High High
Sepsis 3 78.20 Quite High
Asthma 6 75.60 Quite High
Disease 18 72.64 Quite High
Rhinitis 3 68.32 Quite High
Nasal Polyps 3 66.84 Quite High
Demyelinating Disease 3 63.08 Quite High
Inflammatory Bowel Disease 3 59.80 Quite High
Atherosclerosis 3 56.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, IL-17, and PGE2, which are known to contribute to the pathogenesis of OA, also downregulate PPAR?
IL-17 Negative_regulation (downregulate) of PPAR associated with osteoarthritis
1) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 1.33 Pain Relevance 0.39
, IL-17, and PGE2 also downregulated PPAR?
IL-17 Negative_regulation (downregulated) of PPAR
2) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.26 Pain Relevance 0.13
, IL-17, and prostaglandin E2 (PGE2), which are involved in the pathogenesis of OA, also downregulated PPAR?
IL-17 Negative_regulation (downregulated) of PPAR associated with osteoarthritis
3) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906809 Disease Relevance 0.87 Pain Relevance 0.47

General Comments

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