INT209924

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 4.38
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARA) small molecule metabolic process (PPARA) aging (IL1B)
DNA binding (PPARA) lipid metabolic process (PPARA) cell-cell signaling (IL1B)
IL1B (Homo sapiens)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 75 100.00 Very High Very High Very High
Inflammation 240 97.52 Very High Very High Very High
cytokine 60 94.12 High High
Osteoarthritis 975 93.92 High High
Arthritis 30 88.52 High High
Inflammatory stimuli 15 57.20 Quite High
metalloproteinase 30 18.96 Low Low
COX-2 inhibitor 15 5.00 Very Low Very Low Very Low
cINOD 15 5.00 Very Low Very Low Very Low
Multiple sclerosis 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 345 100.00 Very High Very High Very High
Osteoarthritis 990 93.92 High High
Arthritis 60 88.52 High High
Repression 15 86.32 High High
Disease 90 45.60 Quite Low
Sepsis 15 10.80 Low Low
Asthma 30 8.20 Low Low
Obesity 30 5.00 Very Low Very Low Very Low
Demyelinating Disease 15 5.00 Very Low Very Low Very Low
Death 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, PD98059, a selective inhibitor of ERK, had no effect on IL-1-induced downregulation of PPAR?
IL-1 Negative_regulation (downregulation) of PPAR
1) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.14 Pain Relevance 0.04
B mediate IL-1-induced downregulation of PPAR?
IL-1 Negative_regulation (downregulation) of PPAR
2) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.06 Pain Relevance 0.03
B in the IL-1-induced downregulation of PPAR?
IL-1 Negative_regulation (downregulation) of PPAR
3) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.42 Pain Relevance 0.24
B in the IL-1-mediated downregulation of PPAR?
IL-1-mediated Negative_regulation (downregulation) of PPAR
4) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0 Pain Relevance 0
As shown in Figure 6a, IL-1 reduced PPAR?
IL-1 Negative_regulation (reduced) of PPAR
5) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.09 Pain Relevance 0.04
We found that SB203580 and SP600125 – specific inhibitors of the MAPKs p38 and JNK, respectively – almost completely abolished the IL-1-mediated downregulation of PPAR?
IL-1-mediated Negative_regulation (downregulation) of PPAR
6) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.11 Pain Relevance 0.06
This effect probably occurred at the transcriptional level, because IL-1 decreases both PPAR?
IL-1 Negative_regulation (decreases) of PPAR
7) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906809 Disease Relevance 0.81 Pain Relevance 0.41
Downregulation by IL-1 of PPAR?
IL-1 Negative_regulation (Downregulation) of PPAR
8) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.30 Pain Relevance 0.15
The MAPKs JNK and p38, but not ERK, are involved in IL-1-induced downregulation of PPAR?
IL-1 Negative_regulation (downregulation) of PPAR
9) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.14 Pain Relevance 0.07
Mediation of IL-1-induced downregulation of PPAR?
IL-1 Negative_regulation (downregulation) of PPAR
10) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.15 Pain Relevance 0.03
The IL-1-induced downregulation of PPAR?
IL-1 Negative_regulation (downregulation) of PPAR
11) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906809 Disease Relevance 0.45 Pain Relevance 0.24
Pretreatment with SB203580, a specific p38 MAPK inhibitor, as well as pretreatment with SP600125, a selective inhibitor of JNK, dose-dependently abolished IL-1-induced downregulation of PPAR?
IL-1 Negative_regulation (downregulation) of PPAR
12) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.13 Pain Relevance 0.04
Taken together, these data strongly suggest that IL-1 suppressed PPAR?
IL-1 Negative_regulation (suppressed) of PPAR
13) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.13 Pain Relevance 0.07
As shown in Figure 5b, IL-1 suppressed PPAR?
IL-1 Negative_regulation (suppressed) of PPAR
14) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.08 Pain Relevance 0.04
In addition, the observation that IL-1 and other pro-inflammatory mediators downregulate PPAR?
IL-1 Negative_regulation (downregulate) of PPAR associated with inflammatory mediators
15) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 1.37 Pain Relevance 0.72

General Comments

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