INT209926

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.45
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARA) small molecule metabolic process (PPARA) aging (IL1B)
DNA binding (PPARA) lipid metabolic process (PPARA) cell-cell signaling (IL1B)
Anatomy Link Frequency
cartilage 1
IL1B (Homo sapiens)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 260 100.00 Very High Very High Very High
cytokine 16 100.00 Very High Very High Very High
Inflammation 64 89.76 High High
Inflammatory mediators 20 50.04 Quite High
Multiple sclerosis 4 42.48 Quite Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 264 100.00 Very High Very High Very High
INFLAMMATION 92 89.76 High High
Obesity 8 80.12 Quite High
Atherosclerosis 4 54.56 Quite High
Inflammatory Bowel Disease 4 49.04 Quite Low
Repression 4 45.20 Quite Low
Demyelinating Disease 4 42.48 Quite Low
Asthma 8 37.04 Quite Low
Nasal Polyps 4 34.72 Quite Low
Rhinitis 4 31.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in OA and normal cartilage, and studied the effect of IL-1, a prominent cytokine in OA, on PPAR?
IL-1 Regulation (effect) of PPAR in cartilage associated with osteoarthritis and cytokine
1) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.82 Pain Relevance 0.43
A dose-dependent effect of IL-1 on PPAR?
IL-1 Regulation (effect) of PPAR
2) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.20 Pain Relevance 0.13
Time-course and dose-dependent effect of IL-1 on PPAR?
IL-1 Regulation (effect) of PPAR
3) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.74 Pain Relevance 0.33
We therefore evaluated the effect of IL-1, one of the most prominent mediators in OA, on PPAR?
IL-1 Regulation (effect) of PPAR associated with osteoarthritis
4) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.70 Pain Relevance 0.31

General Comments

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