INT209928

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.69
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B, MAPK14) signal transduction (IL1B, MAPK14) nucleoplasm (MAPK14)
aging (IL1B) response to stress (MAPK14) cytoplasm (MAPK14)
Anatomy Link Frequency
chondrocytes 1
IL1B (Homo sapiens)
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 271 99.12 Very High Very High Very High
Inflammatory stimuli 3 72.56 Quite High
Inflammatory mediators 5 64.40 Quite High
Inflammation 48 58.96 Quite High
cytokine 20 52.08 Quite High
Arthritis 18 39.56 Quite Low
metalloproteinase 14 16.08 Low Low
Multiple sclerosis 1 11.04 Low Low
Pain 4 7.56 Low Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 274 99.12 Very High Very High Very High
INFLAMMATION 51 72.24 Quite High
Arthritis 22 39.56 Quite Low
Stress 2 38.32 Quite Low
Disease 16 32.84 Quite Low
Sepsis 1 26.16 Quite Low
Asthma 2 23.56 Low Low
Rhinitis 1 16.28 Low Low
Nasal Polyps 1 14.80 Low Low
Demyelinating Disease 1 11.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[36], however, activation of endogenously expressed p38-MAPK family members by IL-1?
IL-1 Positive_regulation (activation) of p38
1) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.64 Pain Relevance 0.32
Although, when over expressed in transfected cells, each p38 family member can be activated by IL-1?
IL-1 Positive_regulation (activated) of p38
2) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.68 Pain Relevance 0.37
The MAPKs JNK, p38, and ERK are activated by IL-1 and mediate many of the effects of IL-1 in chondrocytes [20].
IL-1 Positive_regulation (activated) of p38 in chondrocytes
3) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.37 Pain Relevance 0.19

General Comments

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