INT209928

Context Info Confidence 0.15 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.69 Pain Relevance 0.87

cytosol (IL1B, MAPK14) signal transduction (IL1B, MAPK14) nucleoplasm (MAPK14) aging (IL1B) response to stress (MAPK14) cytoplasm (MAPK14)

Anatomy Link Frequency chondrocytes 1 IL1B (Homo sapiens) MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 271 99.12 Inflammatory stimuli 3 72.56 Inflammatory mediators 5 64.40 Inflammation 48 58.96 cytokine 20 52.08 Arthritis 18 39.56 metalloproteinase 14 16.08 Multiple sclerosis 1 11.04 Pain 4 7.56 rheumatoid arthritis 8 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 274 99.12 INFLAMMATION 51 72.24 Arthritis 22 39.56 Stress 2 38.32 Disease 16 32.84 Sepsis 1 26.16 Asthma 2 23.56 Rhinitis 1 16.28 Nasal Polyps 1 14.80 Demyelinating Disease 1 11.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

[36], however, activation of endogenously expressed p38-MAPK family members by IL-1?

IL-1 Positive_regulation (activation) of p38

1) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.64 Pain Relevance 0.32

Although, when over expressed in transfected cells, each p38 family member can be activated by IL-1?

IL-1 Positive_regulation (activated) of p38

2) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.68 Pain Relevance 0.37

The MAPKs JNK, p38, and ERK are activated by IL-1 and mediate many of the effects of IL-1 in chondrocytes [20].

IL-1 Positive_regulation (activated) of p38 in chondrocytes

3) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.37 Pain Relevance 0.19

General Comments

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