INT209932

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8, IL1B) nucleoplasm (MAPK8) mitochondrion (MAPK8)
aging (IL1B) cell-cell signaling (IL1B) response to stress (MAPK8)
MAPK8 (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 1 51.08 Quite High
Osteoarthritis 65 47.64 Quite Low
Inflammatory mediators 5 42.92 Quite Low
Inflammation 16 37.48 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 23 50.76 Quite High
Osteoarthritis 66 50.00 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Asthma 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the MAPKs JNK and p38, but not ERK, mediate IL-1-induced downregulation of PPAR?
JNK Positive_regulation (mediate) of IL-1
1) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

This test has worked.

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