INT209934

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B, MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
aging (IL1B) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
chondrocytes 1
IL1B (Homo sapiens)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 1 72.76 Quite High
Osteoarthritis 65 69.32 Quite High
Inflammatory mediators 5 64.60 Quite High
Inflammation 16 59.16 Quite High
Multiple sclerosis 1 11.24 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 23 72.44 Quite High
Osteoarthritis 66 69.32 Quite High
Sepsis 1 26.36 Quite Low
Asthma 2 23.76 Low Low
Disease 6 20.80 Low Low
Rhinitis 1 16.48 Low Low
Nasal Polyps 1 15.00 Low Low
Demyelinating Disease 1 11.24 Low Low
Inflammatory Bowel Disease 1 7.96 Low Low
Atherosclerosis 1 5.08 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MAPKs JNK, p38, and ERK are activated by IL-1 and mediate many of the effects of IL-1 in chondrocytes [20].
IL-1 Positive_regulation (activated) of JNK in chondrocytes
1) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.37 Pain Relevance 0.19

General Comments

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