INT209936

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.95
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14)
nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 104 84.00 Quite High
Inflammation 58 76.88 Quite High
cytokine 12 76.72 Quite High
Inflammatory response 5 61.00 Quite High
Inflammatory stimuli 3 60.56 Quite High
Inflammatory mediators 7 52.40 Quite High
cva 2 14.24 Low Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 38 99.52 Very High Very High Very High
Pancreatitis 56 98.20 Very High Very High Very High
Cancer 197 97.56 Very High Very High Very High
Apoptosis 109 97.08 Very High Very High Very High
Injury 5 95.40 Very High Very High Very High
Disease 22 94.36 High High
Bladder Cancer 6 85.92 High High
Osteoarthritis 106 84.00 Quite High
Infection 3 79.76 Quite High
Critical Illness 2 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed a high expression of p38 MAPK (ATF-2) at 4 ?
Negative_regulation (showed) of Gene_expression (expression) of p38
1) Confidence 0.20 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2864039 Disease Relevance 0.13 Pain Relevance 0
We found that SB203580 and SP600125 – specific inhibitors of the MAPKs p38 and JNK, respectively – almost completely abolished the IL-1-mediated downregulation of PPAR?
Negative_regulation (inhibitors) of Gene_expression (respectively) of p38
2) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.17 Pain Relevance 0.09
The observed increase in phosphorylation of p38 MAPKs and c-Jun N-terminal kinase 1/2 (JNK1/2) was inhibited by the use of the singlet oxygen scavenger L-histidine, showing that MAPKs pathways are activated via the induction of oxidative stress in HK-1 cells, whereas blocking the expression p38a MAPK (p38a) and p38b MAPK (p38b) isoforms of the MAPKs enhanced the HY-PDT-induced apoptosis of HK-1.
Negative_regulation (blocking) of Gene_expression (expression) of p38a associated with stress, cancer and apoptosis
3) Confidence 0.10 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.46 Pain Relevance 0.06
The observed increase in phosphorylation of p38 MAPKs and c-Jun N-terminal kinase 1/2 (JNK1/2) was inhibited by the use of the singlet oxygen scavenger L-histidine, showing that MAPKs pathways are activated via the induction of oxidative stress in HK-1 cells, whereas blocking the expression p38a MAPK (p38a) and p38b MAPK (p38b) isoforms of the MAPKs enhanced the HY-PDT-induced apoptosis of HK-1.
Negative_regulation (blocking) of Gene_expression (expression) of p38a associated with stress, cancer and apoptosis
4) Confidence 0.10 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.51 Pain Relevance 0.06
Based on an experimental model inhibition of expression of pancreatic p38 MAPK and JNK and up-regulation of ERK1/2 expression by APC treatment may theoretically protect against pancreatic injury and ameliorate the disease [8].
Negative_regulation (inhibition) of Gene_expression (expression) of p38 associated with injury and disease
5) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 1.27 Pain Relevance 0.07
The mechanisms by which these drugs exert their effect occur through the downregulation of ERK1/2 and p38 MAP kinase activation, but not that of SAPK/JNK.
Negative_regulation (downregulation) of Gene_expression (activation) of p38 MAP kinase
6) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.36 Pain Relevance 0.22
Activation of p38 was also significantly reduced in the LPS treated synoviocytes, and SNP treated Raw 264.7 cells and synoviocytes, but the expression ERK and p38 was also reduced, indicating that blocking of the activation of p38 and ERK was not specific (Fig. 1A and 1B).
Negative_regulation (reduced) of Gene_expression (expression) of p38
7) Confidence 0.07 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.05 Pain Relevance 0.03

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