INT209948

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 11.51
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CLEC3B) extracellular region (CLEC3B) cytoplasm (CLEC3B)
Anatomy Link Frequency
saliva 3
colon 2
ovary 1
knee 1
CLEC3B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Pain 13 91.60 High High
backache 4 88.64 High High
imagery 1 78.40 Quite High
cytokine 1 63.36 Quite High
Osteoarthritis 91 60.56 Quite High
rheumatoid arthritis 2 50.40 Quite High
Arthritis 1 24.08 Low Low
bradykinin 2 9.20 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 100.00 Very High Very High Very High
Skin Cancer 376 99.92 Very High Very High Very High
Cancer 170 99.44 Very High Very High Very High
Colon Cancer 16 98.68 Very High Very High Very High
Cervical Cancer 8 98.60 Very High Very High Very High
Disease 97 97.24 Very High Very High Very High
Malignant Neoplastic Disease 8 97.16 Very High Very High Very High
Intervertebral Disk Degeneration 39 95.76 Very High Very High Very High
Alzheimer's Dementia 8 91.88 High High
Pain 11 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations suggest that tetranectin may be produced locally by cells of the stromal compartment of tumours and then deposited into the ECM.
Gene_expression (produced) of tetranectin associated with cancer
1) Confidence 0.78 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.36 Pain Relevance 0
Tetranectin is present in the stroma of breast, ovary, colon cancers but not present in corresponding normal tissue [56,57].
Neg (not) Gene_expression (present) of Tetranectin in colon associated with colon cancer
2) Confidence 0.68 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.29 Pain Relevance 0
Based on immunohistochemistry (IHC) studies, tetranectin was found in a fibrillar-like pattern in the ECM around the tumour islands but not detectable in the normal colon stromal tissue.
Neg (not) Gene_expression (found) of tetranectin in colon associated with cancer
3) Confidence 0.67 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.36 Pain Relevance 0
One of the down-regulated proteins in OSCC patientsÂ’ sera was identified as tetranectin, which is a ubiquitously expressed lectin protein.
Gene_expression (expressed) of tetranectin associated with skin cancer
4) Confidence 0.60 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.39 Pain Relevance 0
Tetranectin was found significantly under-expressed in serum (p = 0.03) and saliva (p = 0.007) of metastatic OSCC compared to primary OSCC.
Gene_expression (expressed) of Tetranectin in saliva associated with skin cancer
5) Confidence 0.60 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.07 Pain Relevance 0
Tetranectin was found significantly under-expressed in both serum and saliva of metastatic OSCC compared to primary OSCC.
Gene_expression (expressed) of Tetranectin in saliva associated with skin cancer
6) Confidence 0.60 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2956083 Disease Relevance 1.03 Pain Relevance 0
We further measured the levels of tetranectin from patients with metastatic and primary OSCC, and both serum and saliva tetranectin was found significantly reduced in patients with metastatic OSCC.

2.

Gene_expression (levels) of tetranectin in saliva associated with skin cancer
7) Confidence 0.53 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.32 Pain Relevance 0
Tetranectin is present in the stroma of breast, ovary, colon cancers but not present in corresponding normal tissue [56,57].
Neg (not) Gene_expression (present) of Tetranectin in ovary associated with colon cancer
8) Confidence 0.23 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 1.29 Pain Relevance 0
Demonstrating expression of hemopexin, tetranectin, inter-?
Gene_expression (expression) of tetranectin
9) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906814 Disease Relevance 0.30 Pain Relevance 0.08
Besides, Valdes have tested polymorphisms of genes that express inflammatory factors, and found some of the same polymorphisms, such as CD36, COX2, NCOR2, TNA and ESR1, affecting knee OA susceptibility, were also associated with radiographic progression of lumbar disc degeneration 56.
Gene_expression (express) of TNA in knee associated with intervertebral disk degeneration, inflammation and cox2
10) Confidence 0.05 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 1.09 Pain Relevance 0.52

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