INT209959

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.90
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD80) intracellular (CD80) cell-cell signaling (CD80)
Anatomy Link Frequency
CD86 4
CD80 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 81 99.20 Very High Very High Very High
rheumatoid arthritis 63 95.76 Very High Very High Very High
Inflammation 20 87.28 High High
psoriasis 2 86.00 High High
cytokine 38 75.12 Quite High
methotrexate 2 61.44 Quite High
tolerance 9 60.32 Quite High
chemokine 23 50.80 Quite High
cva 2 45.00 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 63 95.76 Very High Very High Very High
INFLAMMATION 21 87.28 High High
Psoriasis 2 86.00 High High
Disease 15 85.00 Quite High
Synovitis 12 55.36 Quite High
Anaerobic Bacterial Infections 32 50.00 Quite Low
Cv General 3 Under Development 2 45.00 Quite Low
Renal Disease 10 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It selectively modulates the co-stimulatory pathway of T-cell activation by preventing the engagement of CD80/CD86 on APCs with CD28 on T cells.
Negative_regulation (preventing) of CD80 Binding (engagement) of in CD86
1) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.46 Pain Relevance 0.51
Abatacept, a selective co-stimulation modulator, inhibits CD28-dependent T-cell activation by binding to CD80 and CD86 [4].
Negative_regulation (inhibits) of CD80 Binding (binding) of in CD86 associated with abatacept
2) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906816 Disease Relevance 0.28 Pain Relevance 0.84
Insufficient blockade of CD28/B7 interaction may partly account for the limited results obtained in NHP models.
Negative_regulation (blockade) of B7 Binding (interaction) of
3) Confidence 0.26 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.17 Pain Relevance 0.17

General Comments

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