INT209970

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.69
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr83) plasma membrane (Gpr83) signal transducer activity (Gpr83)
Anatomy Link Frequency
nerve trunks 4
peripheral nerves 1
Gpr83 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 276 96.96 Very High Very High Very High
Calcium channel 6 95.24 Very High Very High Very High
Peripheral nerve stimulation 12 89.04 High High
Neuronal nitric oxide synthase 12 84.56 Quite High
sodium channel 6 71.08 Quite High
tetrodotoxin 12 70.36 Quite High
Neurotransmitter 24 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
unmyelinated 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Celiac Disease 192 96.28 Very High Very High Very High
Apoptosis 12 36.32 Quite Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Vibrio Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also showed that GIR was unaffected when the peripheral nerves were selectively superfused for at least 15 min with cadmium chloride 103 µM (an inorganic calcium channel blocker), or calcium free solution.
Neg (unaffected) Negative_regulation (unaffected) of GIR in peripheral nerves associated with calcium channel
1) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0.29 Pain Relevance 0.55
6) which revealed an inhibition of the GIR (Fig. 3e).
Negative_regulation (inhibition) of GIR
2) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0 Pain Relevance 0.03
We confirmed the involvement of ceramide in the organisation of the reflex by showing that superfusion of the nerve trunks with GW4869 blocked the GIR triggered by gastric distension (Fig. 2c).
Negative_regulation (blocked) of GIR in nerve trunks
3) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0.21 Pain Relevance 0.06
When the nerve trunks connecting the coeliac plexus to the viscera were selectively superfused with 13 µM BAPTA/AM for at least 30 min, gastric distension failed to affect significantly the duodenal contractions which revealed an inhibition of the GIR (paired t test, non significant, df?
Negative_regulation (paired) of GIR in nerve trunks associated with celiac disease
4) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0.10 Pain Relevance 0.12
CD treatment of the nerve trunks prevented the increase in ceramide during GIR (unpaired t test, non significant, df?
Negative_regulation (unpaired) of GIR in nerve trunks
5) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0 Pain Relevance 0.04
When the nerve trunks connecting the coeliac plexus to the viscera were selectively superfused with 13 µM BAPTA/AM for at least 30 min, gastric distension failed to affect significantly the duodenal contractions which revealed an inhibition of the GIR (paired t test, non significant, df?
Negative_regulation (inhibition) of GIR in nerve trunks associated with celiac disease
6) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0.10 Pain Relevance 0.12

General Comments

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