INT209971

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.28
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr83) plasma membrane (Gpr83) signal transducer activity (Gpr83)
Anatomy Link Frequency
nerve 1
stomach 1
Gpr83 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 138 98.80 Very High Very High Very High
agonist 6 85.92 High High
Calcium channel 3 49.92 Quite Low
cerebral cortex 2 46.64 Quite Low
Neurotransmitter 12 35.32 Quite Low
Peripheral nerve stimulation 6 32.88 Quite Low
tolerance 12 30.00 Quite Low
sodium channel 3 14.92 Low Low
tetrodotoxin 6 14.20 Low Low
Neuronal nitric oxide synthase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Celiac Disease 96 96.44 Very High Very High Very High
Body Weight 32 95.52 Very High Very High Very High
Hyperinsulinism 12 73.44 Quite High
Hyperglycemia 4 46.36 Quite Low
Obesity 28 22.24 Low Low
Insulin Resistance 4 18.48 Low Low
Stress 8 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, GhrR KO mice fed a HFD are more insulin sensitive compared to WT mice as determined by their significantly increased GIR during the HG clamp.
Positive_regulation (increased) of GIR
1) Confidence 0.40 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.18 Pain Relevance 0
Significant increases in the GIR of LFD-fed GhrR KO mice (41.0 ± 1.4 mg/kg/min) vs WT littermates (33.1 ± 2.1 mg/kg/min) as well as HFD-fed GhrR KO mice (29.1 ± 2.1 mg/kg/min) vs WT (22.0 ± 2.3 mg/kg/min) were observed (Figure 3A).
Positive_regulation (increases) of GIR
2) Confidence 0.40 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.53 Pain Relevance 0
We clearly observed that during the GIR, among all major lipid classes only ceramide selectively increased 7-fold (unpaired t test, P<0.001, df?
Positive_regulation (increased) of GIR
3) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0.15 Pain Relevance 0.33
These results suggest that ceramide production in the nerve fibres is necessary for the organisation of GIR.
Positive_regulation (necessary) of GIR in nerve
4) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0.21 Pain Relevance 0.09
Gastric distensions used to trigger the GIR were within a physiological range since they bring the stomach to a volume similar to that observed when full of nutriments.
Positive_regulation (trigger) of GIR in stomach
5) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0.21 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox