INT209975

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr83) plasma membrane (Gpr83) signal transducer activity (Gpr83)
Anatomy Link Frequency
nerve 1
Gpr83 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 46 96.72 Very High Very High Very High
Neurotransmitter 6 94.04 High High
unmyelinated 1 43.68 Quite Low
Inflammatory response 12 35.04 Quite Low
cytokine 44 34.20 Quite Low
chemokine 2 20.16 Low Low
ketamine 24 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
Morphine 12 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 78 89.36 High High
Aging 1 76.32 Quite High
Apoptosis 4 75.72 Quite High
Fungal Infection 2 42.08 Quite Low
INFLAMMATION 38 35.04 Quite Low
Celiac Disease 32 32.60 Quite Low
Death 8 6.88 Low Low
Infection 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the complex RP105-MD1 interacts directly with the TLR4 signalling complex, preventing its ability to bind LPS.
RP105 Binding (interacts) of
1) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.14 Pain Relevance 0
Modulation of the RP105-MD1 complex could help abolish TLR4 overstimulation.
RP105 Binding (complex) of
2) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.21 Pain Relevance 0
So during the functioning of the autonomic networks involved in the organization of the GIR, the same molecule, NO, is involved in both the conduction of excitation without action potentials within the nerve fibres and in the communication between the neurons of the ganglionic networks.
GIR Binding (organization) of in nerve associated with action potential
3) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1906860 Disease Relevance 0.15 Pain Relevance 0.19

General Comments

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