INT210

Context Info Confidence 0.43 First Reported 1977 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 4.06 Pain Relevance 0.49

enzyme regulator activity (Sln)

Anatomy Link Frequency nerves 2 node 1 trachea 1 Sln (Rattus norvegicus)

Pain Link Frequency Relevance Heat lidocaine 1 99.48 Codeine 5 97.84 depression 1 92.08 imagery 7 84.32 Potency 1 82.64 transdermal 36 50.00 anesthesia 6 8.28 Bioavailability 19 5.00 Inflammation 19 5.00 rheumatoid arthritis 2 5.00

Disease Link Frequency Relevance Heat Melanoma 45 99.80 Cough 10 99.54 Metastasis 77 99.44 Cancer 136 99.08 Esophageal Cancer 26 95.88 Disease 32 95.32 Paralysis 4 95.00 Increased Venous Pressure Under Development 1 93.84 Depression 1 92.08 Recurrence 38 90.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A high amount of flurbiprofen could be incorporated in the SLN and NLC dispersions.

Positive_regulation (incorporated) of SLN

1) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651881 Disease Relevance 0 Pain Relevance 0

Measurement of zeta potential of SLN and NLC enriched hydrogels

Positive_regulation (potential) of SLN

2) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651881 Disease Relevance 0 Pain Relevance 0

Electrical stimulation of SLN elicited identical responses.

Positive_regulation (stimulation) of SLN in SLN

3) Confidence 0.40 Published 1977 Journal Am. J. Physiol. Section Abstract Doc Link 18025 Disease Relevance 0.45 Pain Relevance 0.19

Fictive coughs induced by electrical stimulation of the SLN or mechanical stimulation of the intrathoracic trachea consisted of large-amplitude bursts in phrenic discharge immediately followed by large bursts in cranial iliohypogastric discharge.

Positive_regulation (stimulation) of SLN in trachea associated with cough

4) Confidence 0.40 Published 1991 Journal J. Appl. Physiol. Section Abstract Doc Link 1778930 Disease Relevance 0.88 Pain Relevance 0.08

The microscopic appearance and the structural characterization of cetyl palmitate based SLN with insulin were performed using TEM (Figure 1).

Positive_regulation (based) of SLN

5) Confidence 0.33 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676823 Disease Relevance 0 Pain Relevance 0.04

In the advanced tumor stage, the lymphatics get blocked by the cancer cell permeation and emboli; the dye does not reach the SLN at all, leading to non-detection of SLNs.[1617] The detection of SLN in our study was higher in lower esophageal tumors (85%) than in mid-esophageal tumors (75%), but it was not statistically significant (P value >0.05).

Neg (not) Positive_regulation (reach) of SLN associated with cancer and esophageal cancer

6) Confidence 0.29 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003219 Disease Relevance 0.94 Pain Relevance 0

Recent studies, however, have suggested that a repeat SLN can be performed after a previous SLN biopsy, and sometimes after an axillary node dissection.

Positive_regulation (performed) of SLN in node

7) Confidence 0.26 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2828445 Disease Relevance 1.10 Pain Relevance 0

The improvement of experience with the blue dye procedure along with the addition of radioisotope marking of the SLN contributed to the increase of the number of SLN are biopsied.

Positive_regulation (increase) of SLN

8) Confidence 0.23 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3018621 Disease Relevance 0.15 Pain Relevance 0

If a SLN is found to be positive for melanoma metastases in this way, the completion of a regional lymphadenectomy during the same surgical procedure for SLN biopsy is feasible.

Positive_regulation (positive) of SLN associated with melanoma and metastasis

9) Confidence 0.09 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1592125 Disease Relevance 0.38 Pain Relevance 0

This serial response of the two nerves was identical to that induced by electrical stimulation of the SLN.

Positive_regulation (stimulation) of SLN in nerves

10) Confidence 0.06 Published 2005 Journal Neurosci. Res. Section Abstract Doc Link 16040147 Disease Relevance 0.17 Pain Relevance 0.19

General Comments

This test has worked.