INT210002

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.00
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
synapse 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 160 100.00 Very High Very High Very High
Neurotransmitter 4 97.96 Very High Very High Very High
Endocannabinoid 287 97.52 Very High Very High Very High
depression 108 93.76 High High
antidepressant 90 92.56 High High
antagonist 33 91.24 High High
fluoxetine 10 87.32 High High
amygdala 35 85.12 High High
GABAergic 8 74.32 Quite High
long-term potentiation 10 73.36 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 190 97.72 Very High Very High Very High
Depression 129 93.76 High High
Targeted Disruption 50 87.24 High High
Convulsion 2 67.84 Quite High
Neurodegenerative Disease 27 64.96 Quite High
Shock 8 63.60 Quite High
Post-traumatic Stress Disorder 6 9.48 Low Low
Traumatic Stress Disorders 4 9.24 Low Low
Phobia 4 7.84 Low Low
Stress 87 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an attempt to provide an explanation for these conflicting results, further investigations aimed at evaluating the effect of the increase of CB 1 activation and CB1 receptor blockade under identical experimental conditions and assessing the activation and blockade of CB1 receptors in different animal models of depression should be performed.
Positive_regulation (increase) of Positive_regulation (activation) of CB 1 associated with depression
1) Confidence 0.47 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.38 Pain Relevance 0.46
The authors further investigated whether pharmacologic augmentation of CB1 activation would lead to enhancements in extinction.
Spec (whether) Positive_regulation (augmentation) of Spec (whether) Positive_regulation (activation) of CB1
2) Confidence 0.43 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906867 Disease Relevance 0.55 Pain Relevance 0.32
Interestingly, CB1 activation stimulates NPY release [28] therefore a positive feed-back loop between endocannabinoids and ghrelin-induced NPY would partly explain the lack of effect in CB1-KO animals.
Positive_regulation (stimulates) of Positive_regulation (activation) of CB1 associated with endocannabinoid
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.38
Activation of postsynaptic receptors, at diverse neuronal types, induces the release of endogenous cannabinoid compounds that move backwards across the synapse, until reaching the cannabinoid CB1 receptor, to which they bind, therefore inhibiting further neurotransmitter release.
Positive_regulation (induces) of Positive_regulation (reaching) of cannabinoid CB1 receptor in synapse associated with neurotransmitter and cannabinoid
4) Confidence 0.37 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906867 Disease Relevance 0.07 Pain Relevance 0.37

General Comments

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