INT210011

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
nucleus 2
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 246 99.98 Very High Very High Very High
antagonist 6 97.96 Very High Very High Very High
Intracerebroventricular 3 81.32 Quite High
withdrawal 18 62.08 Quite High
Neuropeptide 12 47.92 Quite Low
medulla 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Central grey 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Enkephalin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 162 99.56 Very High Very High Very High
Stress 33 79.84 Quite High
Anxiety Disorder 117 69.04 Quite High
Pain 3 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Hemorrhage 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A marked increase in steady-state levels of CRH gene expression in the hypothalamic paraventricular nucleus (PVN) was detected after icv PACAP injection, which was blocked by coadministration of a selective PACAP receptor antagonist (Grinevich et al. [6]).
Negative_regulation (blocked) of Gene_expression (injection) of PACAP in nucleus associated with antagonist
1) Confidence 0.36 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.28 Pain Relevance 0.15
Intra-CeA PACAP infusion reduces number of shocks without
Negative_regulation (reduces) of Gene_expression (infusion) of PACAP associated with shock and amygdala
2) Confidence 0.36 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.50 Pain Relevance 0.28
The total amount of time spent on burying the electrified shock probe was also significantly decreased by PACAP injection as compared to aCSF controls (Figure 4(c)).
Negative_regulation (decreased) of Gene_expression (injection) of PACAP associated with shock
3) Confidence 0.36 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.44 Pain Relevance 0.26

General Comments

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