INT210020

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.65
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb4) ATPase activity (Abcb4) transmembrane transport (Abcb4)
Anatomy Link Frequency
bile ducts 1
bile 1
Abcb4 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 64 99.36 Very High Very High Very High
adenocard 2 5.84 Low Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gallstones 166 99.70 Very High Very High Very High
Syndrome 64 97.28 Very High Very High Very High
Bacterial Infection 2 94.52 High High
Cardiovascular Disease 4 45.64 Quite Low
Atherosclerosis 2 44.72 Quite Low
Intrahepatic Cholestasis 20 43.88 Quite Low
Primary Sclerosing Cholangitis 8 18.48 Low Low
Sclerosing Cholangitis 2 9.84 Low Low
Recurrence 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has also been shown that substantial amounts of cholesterol are secreted by Mdr2 (-/-) mice on a cholate-supplemented diet and microscopic examination of the gallbladder reveals massive amount of cholesterol crystals and that after 12 weeks, 50% of the Mdr2 (-/-) mice on chow also developed gallstones composed of needlike "anhydrous" cholesterol crystals and mucin [21,22].
Localization (secreted) of Mdr2 associated with gallstones
1) Confidence 0.71 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 0.79 Pain Relevance 0.17
These results and data in the literature therefore strongly suggest that ABCB4 mutations may lead to cholesterol cholelithiasis when residual ABCB4 activity and subsequent biliary phospholipid secretion fall below a critical threshold which may depend on the type of mutation and on other host or environmental factors, including probably bacterial infection of the bile ducts (Carey et al.
Localization (secretion) of ABCB4 in bile ducts associated with bile, bacterial infection and gallstones
2) Confidence 0.66 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 0.86 Pain Relevance 0.05
Judged by the plasma lathosterol to cholesterol ratio, endogenous cholesterol synthesis was increased in exercising mice (0.15 ± 0.03 vs. 0.11 ± 0.02, p < 0.05), while the hepatic mRNA expression of key transporters for biliary cholesterol (Abcg5/g8, Sr-bI) as well as bile acid (Abcb11) and phospholipd (Abcb4) excretion did not change.
Localization (excretion) of Abcb4 in bile associated with bile
3) Confidence 0.61 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2903598 Disease Relevance 0 Pain Relevance 0.13

General Comments

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