INT210029

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.06
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC, PRTN3) plasma membrane (PROC, PRTN3) cytosol (PRTN3)
extracellular space (PROC) extracellular region (PROC) enzyme binding (PRTN3)
Anatomy Link Frequency
extracellular matrix 1
PROC (Homo sapiens)
PRTN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 99.22 Very High Very High Very High
Pain 1 28.92 Quite Low
dexamethasone 1 9.68 Low Low
metalloproteinase 2 7.84 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.22 Very High Very High Very High
Herpes Simplex Virus Infection 8 94.64 High High
Keratitis 1 93.96 High High
Recurrence 4 83.36 Quite High
Injury 12 80.20 Quite High
Corneal Perforation 1 44.84 Quite Low
Pain 1 28.92 Quite Low
Ulcers 1 5.00 Very Low Very Low Very Low
Corneal Neovascularization 1 5.00 Very Low Very Low Very Low
Corneal Opacity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The beneficial effectsof this approach result from the presence of a rich extracellular matrix and collagen which provide a stromal substrate as in our case and anti-inflammatory properties arising from entrapment of inflammatory cells, the presence of various growth factors, inhibition of proteinase activity, and decrease of lipid peroxidation.[3] AM patch has also been reported to be effective in acute ulcerative and necrotizing herpetic stromal keratitis[4] due toreduction of gelatinolytic activity of MMP-9 and increased expression of TIMP-1.[5] These properties may have been responsible for the effective suppression of herpetic inflammation seen in this particular case.
factors Negative_regulation (inhibition) of proteinase in extracellular matrix associated with inflammation, keratitis and herpes simplex virus infection
1) Confidence 0.00 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913057 Disease Relevance 1.06 Pain Relevance 0.18

General Comments

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