INT210058

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 7.93
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (ELF3) nucleolus (ELF3) nucleus (ELF3)
extracellular matrix organization (ELF3) embryo development (ELF3) cytoplasm (ELF3)
Anatomy Link Frequency
spike 1
ELF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 80 100.00 Very High Very High Very High
anesthesia 7 100.00 Very High Very High Very High
Pain 35 97.40 Very High Very High Very High
Pain score 7 96.44 Very High Very High Very High
Morphine 5 94.16 High High
qutenza 10 87.20 High High
Action potential 24 78.24 Quite High
Central nervous system 9 66.64 Quite High
carbamazepine 2 38.88 Quite Low
medulla 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cough 255 100.00 Very High Very High Very High
Proteinuria 9 100.00 Very High Very High Very High
Angiokeratoma 10 99.82 Very High Very High Very High
Hypertension 5 98.98 Very High Very High Very High
Pain 39 97.40 Very High Very High Very High
Neurological Disease 3 96.72 Very High Very High Very High
Neurologic Manifestations 6 95.56 Very High Very High Very High
Gauchers Disease 130 95.20 Very High Very High Very High
Sensorineural Hearing Loss 10 93.84 High High
Disorders Of Creatine Metabolism 10 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Angiokeratoma did not change after 24 months of ERT (30).
Neg (not) Regulation (change) of ERT associated with angiokeratoma
1) Confidence 0.29 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 1.37 Pain Relevance 0.39
Two covariates affected the chitotriosidase decrease under ERT: splenectomy influenced the slope decline and genotype influenced the baseline level (Figure 2b).
Regulation (affected) of ERT
2) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.07 Pain Relevance 0
Influence of covariates on biomarker changes during ERT
Regulation (Influence) of ERT
3) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.07 Pain Relevance 0
We found that the codeine, a potent cough inhibitor in anesthetized cats [34], had little suppressive effect on ERt.
Regulation (effect) of ERt associated with cough and codeine
4) Confidence 0.23 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.98 Pain Relevance 0.53
As such, there is no difference in the response of ERt and ERg to central antitussives and this finding differs markedly from the response of cough to these drugs.
Regulation (response) of ERt associated with cough
5) Confidence 0.23 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 1.00 Pain Relevance 0.52
There were no significant changes in the degree of proteinuria during ERT (p>0.05) (Fig. 1C).


Neg (no) Regulation (changes) of ERT associated with proteinuria
6) Confidence 0.17 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.99 Pain Relevance 0.05
However, pulmonary function or radiological findings do not usually normalize, despite the correction of hematological parameters and the reduction in organ volumes.10 Although worsening pulmonary pressures have been reported after the introduction of ERT, pulmonary hypertension is associated either with poor compliance, or the lack of ERT.46 An emerging concern has been whether ERT could prevent the progression of the neurological disease in neuronopathic GD.
Regulation (lack) of ERT associated with neurological disease, hypertension and gauchers disease
7) Confidence 0.15 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0.74 Pain Relevance 0.03
The ERt/ERg are likely produced and controlled by different mechanisms than the expulsions in cough [5,7,22,35].
Regulation (controlled) of ERt associated with cough
8) Confidence 0.12 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.97 Pain Relevance 0
The effects of general anesthesia on cough and ERt/ERg also differ substantially.
Regulation (effects) of ERt associated with anesthesia and cough
9) Confidence 0.12 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.77 Pain Relevance 0.41
However, the effect of codeine on ERt has not been reported previously.
Regulation (effect) of ERt associated with codeine
10) Confidence 0.10 Published 2008 Journal Cough Section Body Doc Link PMC2405785 Disease Relevance 0.90 Pain Relevance 0.54
Since eRT is dependent on both ?
Regulation (dependent) of eRT
11) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2528963 Disease Relevance 0 Pain Relevance 0
We chose to average the values of eRT and eSIT from templates 20 to 40 ms prior the spike, since these locations gave nearly constant values (Figure 3C).


Regulation (values) of eRT in spike
12) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2528963 Disease Relevance 0 Pain Relevance 0.04
One of our most important observations is that the efficacy of ERT, whether using agalsidase alfa or beta, in general is disappointing.
Spec (whether) Regulation (efficacy) of ERT
13) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.07 Pain Relevance 0

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