INT210072

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.94
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (SH3GL3) endosome (SH3GL3) signal transduction (SH3GL3)
cytoplasm (SH3GL3)
Anatomy Link Frequency
urine 12
plasma 6
SH3GL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Antihistamine 8 76.80 Quite High
corticosteroid 8 75.36 Quite High
imagery 24 58.24 Quite High
Central nervous system 13 58.00 Quite High
Paracetamol 16 41.68 Quite Low
Pain 95 31.20 Quite Low
Pain score 29 31.04 Quite Low
cva 26 22.72 Low Low
Restless leg syndrome 4 10.08 Low Low
ischemia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 71 94.96 High High
Fabry Disease 290 90.44 High High
Hypersensitivity 8 87.92 High High
Disease 146 75.52 Quite High
Fever 18 69.84 Quite High
Chills 8 69.44 Quite High
Congenital Anomalies 16 58.80 Quite High
Left Ventricular Hypertrophy 47 58.68 Quite High
Renal Insufficiency 20 42.80 Quite Low
Sensorineural Hearing Loss 40 40.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERT resulted in decreased plasma and urine GL-3 levels even after a short-term treatment, and reduced GL-3 accumulation in various organs and tissues (24).
Negative_regulation (decreased) of Gene_expression (plasma) of urine GL-3 in urine
1) Confidence 0.31 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.33 Pain Relevance 0
Despite decreased plasma and urine GL-3 levels, there were no significant changes in urinary protein excretion and serum creatinine levels.
Negative_regulation (decreased) of Gene_expression (levels) of urine GL-3 in urine
2) Confidence 0.31 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.24 Pain Relevance 0.10
Despite decreased plasma and urine GL-3 levels, there were no significant changes in urinary protein excretion and serum creatinine levels.
Negative_regulation (decreased) of Gene_expression (plasma) of urine GL-3 in urine
3) Confidence 0.31 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.24 Pain Relevance 0.10
ERT resulted in decreased plasma and urine GL-3 levels even after a short-term treatment, and reduced GL-3 accumulation in various organs and tissues (24).
Negative_regulation (decreased) of Gene_expression (levels) of urine GL-3 in urine
4) Confidence 0.31 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.33 Pain Relevance 0
ERT resulted in decreased plasma and urine GL-3 levels even after a short-term treatment, and reduced GL-3 accumulation in various organs and tissues (24).
Negative_regulation (decreased) of in plasma Gene_expression (levels) of urine GL-3 in urine
5) Confidence 0.11 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.33 Pain Relevance 0
ERT resulted in decreased plasma and urine GL-3 levels even after a short-term treatment, and reduced GL-3 accumulation in various organs and tissues (24).
Negative_regulation (decreased) of in plasma Gene_expression (plasma) of urine GL-3 in urine
6) Confidence 0.11 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.33 Pain Relevance 0
Despite decreased plasma and urine GL-3 levels, there were no significant changes in urinary protein excretion and serum creatinine levels.
Negative_regulation (decreased) of in plasma Gene_expression (plasma) of urine GL-3 in urine
7) Confidence 0.11 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.24 Pain Relevance 0.10
Despite decreased plasma and urine GL-3 levels, there were no significant changes in urinary protein excretion and serum creatinine levels.
Negative_regulation (decreased) of in plasma Gene_expression (levels) of urine GL-3 in urine
8) Confidence 0.11 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526436 Disease Relevance 0.24 Pain Relevance 0.10
B) Are the underlying pathophysiologic processes improved in parallel with reductions in the GL-3 load?
Negative_regulation (reductions) of Gene_expression (load) of GL-3
9) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.22 Pain Relevance 0.03
In all antibody positive males, urinary GL-3 levels failed to decline after 12 months of treatment (126 nmol/24 h, range ?
Neg (failed) Negative_regulation (decline) of Gene_expression (levels) of GL-3
10) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.14 Pain Relevance 0
In all antibody positive males, urinary GL-3 levels failed to decline after 12 months of treatment (126 nmol/24 h, range ?
Neg (failed) Negative_regulation (failed) of Gene_expression (levels) of GL-3
11) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.14 Pain Relevance 0
However, a trend towards higher baseline urinary GL-3 levels was seen in patients with treatment failure (2083 nmol/24 h, range 520 to 5681 (n?
Negative_regulation (trend) of Gene_expression (levels) of GL-3
12) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.17 Pain Relevance 0.03
Antibodies resulted in a less robust decrease of plasma GL-3 levels in male patients after 12 months of treatment (ab+ ?
Negative_regulation (decrease) of Gene_expression (levels) of GL-3 in plasma
13) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0 Pain Relevance 0

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