INT210140

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.83
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
neuronal 2
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 333 99.84 Very High Very High Very High
Nucleus accumbens 9 96.92 Very High Very High Very High
Dopamine 129 95.64 Very High Very High Very High
Eae 63 93.96 High High
fluoxetine 6 91.56 High High
Serotonin 3 82.84 Quite High
Nicotine 3 59.32 Quite High
Neurotransmitter 3 35.36 Quite Low
monoamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 12 88.12 High High
Targeted Disruption 15 82.40 Quite High
Aggression 3 64.96 Quite High
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies indicate that alterations in DAT expression can change an animal's behavior and modify its response to drugs including psychostimulants.
Regulation (alterations) of Gene_expression (expression) of DAT
1) Confidence 0.62 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.29 Pain Relevance 0.52
It is likely that the absence of DAT in DAT-KO mice has altered neuronal signaling pathways.
Regulation (altered) of Neg (absence) Gene_expression (absence) of DAT in neuronal
2) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.35 Pain Relevance 0.75
Our results revealed the effects of reduced DAT expression on cocaine-elicited animal behaviors.


Regulation (effects) of Gene_expression (expression) of DAT associated with cocaine
3) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.19 Pain Relevance 0.55

General Comments

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