INT210160

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2007
Negated 1
Speculated 3
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 4.16
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (TNFRSF8, TXN) signal transduction (TNFRSF8, TXN) nucleoplasm (TXN)
transport (TXN) mitochondrion (TXN) small molecule metabolic process (TXN)
Anatomy Link Frequency
lymphocyte 4
HeLa 1
upper 1
TNFRSF8 (Homo sapiens)
TXN (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 34 100.00 Very High Very High Very High
Inflammation 136 96.80 Very High Very High Very High
agonist 17 96.32 Very High Very High Very High
Inflammatory response 17 70.84 Quite High
rheumatoid arthritis 17 64.92 Quite High
cytokine 51 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 68 99.24 Very High Very High Very High
Stress 51 97.88 Very High Very High Very High
Infection 34 97.36 Very High Very High Very High
INFLAMMATION 153 96.80 Very High Very High Very High
Leukemia 34 94.40 High High
Lymphatic System Cancer 119 92.40 High High
Disease 17 86.24 High High
Necrosis 34 81.84 Quite High
Cancer 34 81.48 Quite High
Viral Infection 51 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The result also suggests that the enzymatic affinity of Trx1 for CD30 has been conserved during mammalian evolution.


CD30 Binding (affinity) of Trx1
1) Confidence 0.47 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.18 Pain Relevance 0
We asked whether this unusual feature might confer Trx1 reactivity to human CD30 and tested whether the shorter murine CD30 could also interact with Trx1.
CD30 Binding (interact) of Trx1
2) Confidence 0.47 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.19 Pain Relevance 0
Given its influence on ligand binding, we reasoned that Trx1 might interfere with CD30-mediated signaling.
CD30 Spec (might) Binding (interfere) of Trx1
3) Confidence 0.36 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.22 Pain Relevance 0.05
CD30/TNFRSF8 is the principal Trx1 sensitive receptor on various lymphoid cell lines
CD30 Binding (receptor) of Trx1
4) Confidence 0.36 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.24 Pain Relevance 0
Applying the approach to the surface of cell lines representative of the lymphoid lineage, we observed that Trx1 basically targets a single cell surface protein, subsequently identified as TNF receptor superfamily member 8, also known as CD30.
CD30 Binding (targets) of Trx1 associated with member 8
5) Confidence 0.36 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0.10
CD30/TNFRSF8 is the principal Trx1 sensitive receptor on various lymphoid cell lines
TNFRSF8 Binding (receptor) of Trx1
6) Confidence 0.36 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.24 Pain Relevance 0
As CD30 is implicated in both stimulatory and apoptotic signaling, our findings suggest that Trx1 interacts with CD30 to modulate lymphocyte behavior and survival under conditions of infection and inflammation.


CD30 Binding (interacts) of Trx1 in lymphocyte associated with inflammation, apoptosis and infection
7) Confidence 0.35 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.44 Pain Relevance 0.05
We demonstrate that disulfide exchange between Trx1 and CD30 interferes with binding of the CD30 ligand (CD30L) to its cognate receptor and that Trx1 affects CD30-dependent changes in lymphocyte effector function.
CD30 Binding (binding) of Trx1 in lymphocyte
8) Confidence 0.35 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.40 Pain Relevance 0.04
The interaction between Trx1 and CD30 might represent a regulatory link between oxidative stress and lymphocyte function.
CD30 Spec (might) Binding (interaction) of Trx1 in lymphocyte associated with stress
9) Confidence 0.35 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.93 Pain Relevance 0.18
To validate the direct covalent interaction between Trx1(CSAAA) and CD30, an aliquot of trapped complexes from the same experiment was separated under non-reducing and reducing conditions and subjected to immunoblotting analysis with anti-Trx1 (Figure 3A, middle panel) and anti-CD30 antibodies (Figure 3A, right panel), respectively.
CD30 Binding (interaction) of Trx1
10) Confidence 0.35 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.11 Pain Relevance 0
Trx1-mediated disulfide exchange interferes with CD30 receptor–ligand interactions
CD30 Binding (interactions) of Trx1
11) Confidence 0.35 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.12 Pain Relevance 0
Treatment of YT cells with Trx1(CCAAA) (but not with redox-inactive Trx1) prevented CD25 upregulation (Figure 7A, lower panel, columns 5 and 8), concomitant with the redox change in CD30 (Figure 7A, upper panel, column 4), thus demonstrating that the redox interaction between Trx1 and CD30 has a pronounced influence on CD30-mediated gene expression.
CD30 Binding (interaction) of Trx1 in upper
12) Confidence 0.35 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.07 Pain Relevance 0.03
Conversely, ectopic overexpression of several related TNFR superfamily members in HeLa cells did not lead to their interaction with Trx1, yet CD30 strongly interacted on the same cells under the same conditions.
CD30 Neg (not) Binding (interaction) of Trx1 in HeLa
13) Confidence 0.35 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.09 Pain Relevance 0
We demonstrate that disulfide exchange between Trx1 and CD30 interferes with binding of the CD30 ligand (CD30L) to its cognate receptor and that Trx1 affects CD30-dependent changes in lymphocyte effector function.
CD30 Binding (binding) of Trx1 in lymphocyte
14) Confidence 0.35 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.40 Pain Relevance 0.04
We asked whether this unusual feature might confer Trx1 reactivity to human CD30 and tested whether the shorter murine CD30 could also interact with Trx1.
CD30 Spec (might) Binding (reactivity) of Trx1
15) Confidence 0.32 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.17 Pain Relevance 0
To demonstrate by an independent method that Trx1 attacks and breaks a disulfide bond in CD30, we used thiol-specific cell surface biotinylation to verify that Trx1 activity generates free thiols within the CD30 ectodomain (Supplementary Figure S3).
CD30 Binding (bond) of Trx1
16) Confidence 0.32 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.17 Pain Relevance 0
We asked whether this unusual feature might confer Trx1 reactivity to human CD30 and tested whether the shorter murine CD30 could also interact with Trx1.
CD30 Binding (interact) of Trx1
17) Confidence 0.30 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.19 Pain Relevance 0

General Comments

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