INT210194

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.17
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TXN) transport (TXN) mitochondrion (TXN)
small molecule metabolic process (TXN) cell-cell signaling (TXN) cytoplasm (TXN)
Anatomy Link Frequency
dendritic cells 6
macrophages 2
TXN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 64 99.72 Very High Very High Very High
cytokine 24 89.28 High High
member 8 16 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 72 99.72 Very High Very High Very High
Viral Infection 24 98.32 Very High Very High Very High
Leukemia 16 93.56 High High
Apoptosis 32 80.16 Quite High
Adhesions 16 64.92 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 60.68 Quite High
Lymphatic System Cancer 56 41.60 Quite Low
Stress 24 5.00 Very Low Very Low Very Low
Necrosis 16 5.00 Very Low Very Low Very Low
Cancer 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Certain Trx1-secreting cell types, including macrophages and dendritic cells, distinctly upregulate expression of Trx1 upon activation (Angelini et al, 2002).
Positive_regulation (upregulate) of Gene_expression (expression) of Trx1 in dendritic cells
1) Confidence 0.46 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
Certain Trx1-secreting cell types, including macrophages and dendritic cells, distinctly upregulate expression of Trx1 upon activation (Angelini et al, 2002).
Positive_regulation (upregulate) of Gene_expression (expression) of Trx1 in dendritic cells
2) Confidence 0.46 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
Extracellular Trx1 is present in the circulation of healthy subjects and its levels increase under inflammatory conditions, including viral infection (Nakamura et al, 2001a).
Positive_regulation (increase) of Gene_expression (present) of Trx1 associated with inflammation and viral infection
3) Confidence 0.42 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.58 Pain Relevance 0.14
Overall Trx1 concentrations in mammalian tissues can be as high as 20 ?
Positive_regulation (Overall) of Gene_expression (concentrations) of Trx1
4) Confidence 0.40 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.09 Pain Relevance 0.04
Overall Trx1 concentrations in mammalian tissues can be as high as 20 ?
Positive_regulation (high) of Gene_expression (concentrations) of Trx1
5) Confidence 0.40 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.09 Pain Relevance 0.04
Overall Trx1 concentrations in mammalian tissues can be as high as 20 ?
Positive_regulation (Overall) of Gene_expression (Overall) of Trx1
6) Confidence 0.40 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.09 Pain Relevance 0.04
Certain Trx1-secreting cell types, including macrophages and dendritic cells, distinctly upregulate expression of Trx1 upon activation (Angelini et al, 2002).
Positive_regulation (upregulate) of in macrophages Gene_expression (expression) of Trx1 in dendritic cells
7) Confidence 0.16 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
Certain Trx1-secreting cell types, including macrophages and dendritic cells, distinctly upregulate expression of Trx1 upon activation (Angelini et al, 2002).
Positive_regulation (upregulate) of in macrophages Gene_expression (expression) of Trx1 in dendritic cells
8) Confidence 0.16 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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