INT210199

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.52
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
regulatory T cells 4
upper 2
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 4 88.60 High High
methotrexate 6 87.88 High High
agonist 1 69.64 Quite High
cytokine 31 50.00 Quite Low
Inflammation 50 37.92 Quite Low
tolerance 16 22.24 Low Low
Arthritis 36 5.00 Very Low Very Low Very Low
rheumatoid arthritis 19 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
abatacept 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 33 100.00 Very High Very High Very High
Fever 4 100.00 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 4 99.04 Very High Very High Very High
Sjoegrens Syndrome 4 94.68 High High
Lymphatic System Cancer 7 81.44 Quite High
Rheumatic Diseases 24 80.76 Quite High
Sarcoidosis 8 77.84 Quite High
Granuloma 2 69.44 Quite High
Systemic Lupus Erythematosus 27 64.68 Quite High
INFLAMMATION 51 37.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Kawasaki disease, Furuno et al. found that during the active phase of the disease, the number of circulating CD4+CD25high regulatory T cells is reduced compared to patients with infectious causes of febrile illness, whose CD4+CD25high regulatory T cell numbers are higher than in healthy subjects.
Negative_regulation (reduced) of Positive_regulation (regulatory T cells) of CD25high in regulatory T cell associated with mucocutaneous lymph node syndrome, fever and disease
1) Confidence 0.15 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.17 Pain Relevance 0.09
In defervesce phase of the disease, the number of CD4+CD25high regulatory T cells in patients with Kawasaki disease increases to/or above normal levels, while CD4+CD25high regulatory T cells in patients with infectious febrile disease decrease to normal levels [138].
Negative_regulation (decrease) of Positive_regulation (regulatory T cells) of CD25high in regulatory T cells associated with mucocutaneous lymph node syndrome, fever and disease
2) Confidence 0.13 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.26 Pain Relevance 0.07
Treatment of YT cells with Trx1(CCAAA) (but not with redox-inactive Trx1) prevented CD25 upregulation (Figure 7A, lower panel, columns 5 and 8), concomitant with the redox change in CD30 (Figure 7A, upper panel, column 4), thus demonstrating that the redox interaction between Trx1 and CD30 has a pronounced influence on CD30-mediated gene expression.
Negative_regulation (prevented) of Positive_regulation (upregulation) of CD25 in upper
3) Confidence 0.09 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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