INT2102

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Context Info
Confidence 0.51
First Reported 1978
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 20
Disease Relevance 1.37
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Lip 7
macrophages 2
sinus 2
plasma 1
gonadotroph 1
Rhd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
Serotonin 1 99.72 Very High Very High Very High
anesthesia 15 99.40 Very High Very High Very High
Somatostatin 1 99.40 Very High Very High Very High
methotrexate 8 98.84 Very High Very High Very High
agonist 1 97.64 Very High Very High Very High
substance P 8 97.44 Very High Very High Very High
Angina 1 97.32 Very High Very High Very High
Spinal cord 4 93.04 High High
Disease Link Frequency Relevance Heat
Cleidocranial Dysplasia 7 100.00 Very High Very High Very High
Thrombosis Related Under Development 1 98.40 Very High Very High Very High
Cv General 3 Under Development 1 97.32 Very High Very High Very High
Prostate Cancer 4 94.00 High High
INFLAMMATION 56 85.76 High High
Pressure And Volume Under Development 1 84.88 Quite High
Stress 1 84.16 Quite High
Urological Neuroanatomy 1 75.00 Quite High
Eye Disease 28 60.48 Quite High
Ocular & Orbital Inflammation 84 58.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, as plasma LH rose to peak concentrations and declined to basal plasma values, rhythmic rises and falls in MBH-LH-RH were observed with intervals between pulses of approximately 60 min.
Gene_expression (rose) of LH-RH in plasma
1) Confidence 0.51 Published 1978 Journal Brain Res. Section Abstract Doc Link 350353 Disease Relevance 0.07 Pain Relevance 0.09
All 37 patients presented RHD with the clinical symptomatology of labral lesions and underwent routine preoperative MRA.
Gene_expression (presented) of RHD associated with cleidocranial dysplasia
2) Confidence 0.49 Published 1998 Journal Orthopade Section Abstract Doc Link 9871925 Disease Relevance 0.54 Pain Relevance 0.07
(D-Met2,Pro5)-enkephalinamide in a concentration range 10(-7)--10(-5) M did not alter the testosterone production and the troph-hormone sensitivity of the isolated Leydig cells, or the gonadotroph hormone release and the luteinizing-hormone--releasing hormone (LH-RH) sensitivity of the isolated anterior pituitary cells.
Gene_expression (production) of LH-RH in gonadotroph
3) Confidence 0.19 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 379712 Disease Relevance 0 Pain Relevance 0.30
The effects of hybrid cytotoxic LH-RH analogs, produced by linking anthraquinone or methotrexate to carrier LH-RH agonist [D-Lys6]LH-RH, were evaluated in Copenhagen-Fisher F1 rats bearing Dunning R-3327H prostate adenocarcinoma.
Gene_expression (produced) of LH-RH associated with agonist, prostate cancer and methotrexate
4) Confidence 0.16 Published 1993 Journal Prostate Section Abstract Doc Link 8378189 Disease Relevance 0.23 Pain Relevance 0.23
At the level of the cornea, no Rh-lip could be detected (not shown).
Neg (not) Gene_expression (detected) of Rh-lip in lip
5) Confidence 0.06 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.17 Pain Relevance 0.08
Twenty-four h and up to 14 days following injection, Rh-Lip was almost exclusively detected in the subcapsular sinus of the cervical LN (Table 2).
Gene_expression (detected) of Rh-Lip in Lip
6) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
Fluorescent liposomes internalized by macrophages in the conjunctiva still contained VIP 24 h following IVT injection of VIP-Rh-Lip, (Figure 3G), but VIP was not detected in conjunctival macrophages after IVT injection of Rh-Lip alone (data not shown).
Gene_expression (injection) of Rh-Lip in macrophages
7) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.05 Pain Relevance 0.03
Distribution of Rh-Lip in the secondary lymphoid organs following intravitreal injection of Rh-Lip
Gene_expression (injection) of Rh-Lip in Lip
8) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
A rare cell containing Rh-Lip was observed in the subcapsular sinus of the mesenteric LN of one animal out of three (Table 2), and only a few cells bearing a limited quantity of Rh-Lip were detected in the marginal zone of the spleen.
Gene_expression (containing) of Rh-Lip in sinus
9) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
In addition, VIP was present in macrophages (Mc, Figure 5E) containing Rh-Lip (Figure 6F) and in small cells expressing CD4 (arrow in Figure 6G,H).
Gene_expression (containing) of Rh-Lip in macrophages
10) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.06 Pain Relevance 0
Following IVT injection of Rh-Lip, fluorescent liposomes were observed in cervical LN as early as 2 h after IVT injection (data not shown).
Gene_expression (injection) of Rh-Lip in Lip
11) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
In the present study, Rh-Lip drainage to the cervical LN more probably results from Rh-Lip deposition in the conjunctival tissue occurring during the IVT injection itself.
Gene_expression (deposition) of Rh-Lip in Lip
12) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
To determine the nature of the small cells adjacent to macrophages in the cervical LN in which VIP was detected, triple immunostaining for VIP (blue), Rh-Lip (red), and T cell markers (green) were performed.
Gene_expression (immunostaining) of Rh-Lip in T cell
13) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
Distribution of Rh-Lip in the secondary lymphoid organs following intravitreal injection of Rh-Lip
Gene_expression (Distribution) of Rh-Lip in Lip
14) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
In animals that received an IVT injection of Rh-Lip that did not contain VIP, there was no VIP detectable in the subcapsular sinus of the cervical LN (data not shown).
Gene_expression (injection) of Rh-Lip in sinus
15) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
Intravitreal injections (IVT) of Rh-Lip (10 ?
Gene_expression (injections) of Rh-Lip in Lip
16) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0.10
In contrast, various amino acids and serotonin (250 microM) produced little or no inhibition of [3H]MeTRH binding, and cholecystokinin, Leu- and Met-enkephalins, angiotensin II, LH-RH, bombesin and somatostatin were also markedly less potent than SP.
Gene_expression (produced) of LH-RH associated with somatostatin, enkephalin, cholecystokinin, serotonin and substance p
17) Confidence 0.04 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6200806 Disease Relevance 0 Pain Relevance 0.87
In lymphoid organs, Rh-Lip and VIP-Rh-Lip were distributed almost exclusively in the cervical lymph nodes (LN) with only a few Rh-Lip-positive cells detected in the spleen and mesenteric LN and none in the inguinal LN.
Gene_expression (detected) of Rh-Lip in cervical lymph nodes
18) Confidence 0.04 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
In the eye, 24 h following IVT injection, fluorescent liposomes (Rh-Lip and VIP-Rh-Lip) were detected mainly in the posterior segment of the eye (vitreous, inner layer of the retina) and to a lesser extent at the level of the iris root and ciliary body.
Gene_expression (detected) of Rh-Lip in ciliary body
19) Confidence 0.04 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2268712 Disease Relevance 0.06 Pain Relevance 0.06
In this report, we have discussed the production of specific polyclonal antibodies to recombinant hirudin (rH) and the development of two ELISA methods to measure rH concentrations in biological fluids: a sandwich and a competitive ELISA method.
Gene_expression (production) of rH
20) Confidence 0.03 Published 1995 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 7660141 Disease Relevance 0.20 Pain Relevance 0.10

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