INT21020

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Context Info
Confidence 0.14
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.85
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rtcd1) molecular_function (Rtcd1) ligase activity (Rtcd1)
Anatomy Link Frequency
corpus 1
ciliary 1
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 73 94.68 High High
Clonidine 1 86.92 High High
Central nervous system 5 85.40 High High
Inflammation 30 84.72 Quite High
cytokine 4 83.68 Quite High
agonist 15 83.36 Quite High
Inflammatory response 5 77.84 Quite High
headache 1 40.80 Quite Low
antagonist 15 39.68 Quite Low
nud 1 39.20 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 91.28 High High
Erectile Dysfunction 2 91.28 High High
INFLAMMATION 18 84.72 Quite High
Adult Respiratory Distress Syndrome 61 67.40 Quite High
Disease 8 63.92 Quite High
Pneumonia 20 56.28 Quite High
Diabetes Mellitus 1 55.60 Quite High
Necrosis 1 49.48 Quite Low
Cancer 1 49.12 Quite Low
Headache 1 40.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that the cholinergic system may have a direct role in modulation of ciliary epithelial adenylate cyclase and aqueous humor secretion.
Localization (secretion) of cyclase in ciliary
1) Confidence 0.14 Published 1990 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 2162335 Disease Relevance 0 Pain Relevance 0.16
A2B is coupled to both Gs and Gq proteins, activating adenylate cyclase and phospholipase C, respectively.
Localization (cyclase) of cyclase
2) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.64 Pain Relevance 0.35
Sexual stimulation triggers the release of nitric oxide (NO), stimulating the release of guanylyl cyclase, leading to an increase in intracellular cyclic guanosine monophosphate (cGMP) concentrations, a decrease in intracellular calcium, and ultimately relaxation of the vascular smooth muscle in the corpus cavernosum and penile erection.
Localization (release) of cyclase in corpus associated with erectile dysfunction
3) Confidence 0.00 Published 2004 Journal Clin Cardiol Section Abstract Doc Link 15115191 Disease Relevance 0.21 Pain Relevance 0

General Comments

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