INT210208

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TNFSF8) signal transduction (TNFSF8) extracellular space (TNFSF8)
cell-cell signaling (TNFSF8)
Anatomy Link Frequency
row 2
HDLM-2 2
TNFSF8 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 94.80 High High
cytokine 6 50.00 Quite Low
Inflammation 16 5.00 Very Low Very Low Very Low
member 8 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 14 98.90 Very High Very High Very High
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Viral Infection 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Epstein-barr Virus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A brief incubation of CD30+Hodgkin's lymphoma HDLM-2 cells with wild-type Trx1 led to a substantial loss in CD30L binding to the cell surface (Figure 6A).
Negative_regulation (loss) of CD30L Binding (binding) of in HDLM-2 associated with lymphatic system cancer
1) Confidence 0.11 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.19 Pain Relevance 0
Treatment of HeLa cells with Trx1(CCAAA) (Figure 6B, middle row) but not a redox-inactive mutant (Figure 6B, lower row) strongly interferes with CD30L binding and colocalization.


Negative_regulation (interferes) of CD30L Binding (binding) of in row
2) Confidence 0.11 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.22 Pain Relevance 0.05

General Comments

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