INT210228

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.78
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Rpe) carbohydrate metabolic process (Rpe)
Anatomy Link Frequency
eyes 3
retina 3
choroid 2
joint 1
photoreceptor 1
Rpe (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 78 92.80 High High
Inflammatory stimuli 1 65.76 Quite High
imagery 24 64.40 Quite High
Inflammatory response 5 45.32 Quite Low
Eae 8 39.80 Quite Low
anesthesia 9 25.52 Quite Low
Inflammatory mediators 1 25.20 Quite Low
Buprenorphine 2 21.12 Low Low
Analgesic 2 20.12 Low Low
Nicotine 4 17.76 Low Low
Disease Link Frequency Relevance Heat
Uveitis 45 100.00 Very High Very High Very High
Injury 61 99.96 Very High Very High Very High
Apoptosis 54 99.76 Very High Very High Very High
Targeted Disruption 13 99.76 Very High Very High Very High
Fatigue 255 99.20 Very High Very High Very High
Myopia 94 98.16 Very High Very High Very High
Hypertrophy 3 97.68 Very High Very High Very High
Hyperplasia 3 97.16 Very High Very High Very High
Age-related Macular Degeneration 381 96.68 Very High Very High Very High
Death 11 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our TUNEL experiments showed a clear increase in RPE cell apoptosis in mice exposed to cigarette smoke.
Spec (clear) Positive_regulation (increase) of RPE associated with apoptosis
1) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.45 Pain Relevance 0
Hahn et al, using a ceruloplasmin and hephaestin double knockout mouse that accumulates iron in the retina and RPE, developed an age-dependent retinal pigmented epithelium hypertrophy, hyperplasia, and death through enhanced oxidative stress [37].
Positive_regulation (accumulates) of RPE in retinal pigmented epithelium associated with stress, targeted disruption, hypertrophy, death and hyperplasia
2) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.44 Pain Relevance 0
Alternatively, because of the significant anti-oxidant capability of the RPE, a chronic exposure to the oxidants in cigarette smoke might be necessary to cause RPE injury and apoptosis.
Positive_regulation (cause) of RPE associated with injury and apoptosis
3) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.44 Pain Relevance 0.04
Figure 2 shows representative results obtained by culturing the RPE-choroid and retina of PER2::LUC mice.
Positive_regulation (culturing) of RPE-choroid in retina
4) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0
Besides this expected increase in RPE, the decrease of joint impedance and the increase of SDDT also indicate that the fatigue protocol was effective.
Positive_regulation (increase) of RPE in joint associated with fatigue
5) Confidence 0.29 Published 2007 Journal Exp Brain Res Section Body Doc Link PMC1914220 Disease Relevance 0.73 Pain Relevance 0
Although there was a significant increase in RPE, concomitant with an increase in neuromuscular noise, no decrease in performance was observed.
Positive_regulation (increase) of RPE
6) Confidence 0.29 Published 2007 Journal Exp Brain Res Section Body Doc Link PMC1914220 Disease Relevance 0.55 Pain Relevance 0
As expected, RPE increased in response to the fatigue protocol.
Positive_regulation (increased) of RPE associated with fatigue
7) Confidence 0.19 Published 2007 Journal Exp Brain Res Section Body Doc Link PMC1914220 Disease Relevance 0.74 Pain Relevance 0
Rosette formation occurs postnatally [10], [17], apparently driven by a metabolic need of the retina, leading to an increased surface area between RPE and photoreceptors.
Positive_regulation (increased) of RPE in retina
8) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759518 Disease Relevance 0.06 Pain Relevance 0.03
Establishment of primary RPE cell cultures from mouse eyes
Positive_regulation (Establishment) of RPE in eyes
9) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0.07 Pain Relevance 0
Double-labeling studies were performed with 1:1,000 chicken polyclonal anti-MCT1 as a positive marker for RPE apical membrane [25,26].
Positive_regulation (marker) of RPE
10) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2642846 Disease Relevance 0 Pain Relevance 0
Figure 2 shows representative results obtained by culturing the RPE-choroid and retina of PER2::LUC mice.
Positive_regulation (culturing) of RPE-choroid in choroid
11) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0
Increased lipofuscin in the RPE can lead to apoptosis, resulting in accumulation of debris on and within Bruch’s membrane, and eventual loss of photoreceptor function.
Positive_regulation (Increased) of RPE in photoreceptor associated with apoptosis
12) Confidence 0.10 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 0.67 Pain Relevance 0.10
Analysis of a 4,000 gene microarray identified the expression of one gene, ATH, to be upregulated in the retina–RPE–choroid following one day of recovery as compared with contralateral control eyes.
Positive_regulation (upregulated) of RPE in eyes
13) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2671582 Disease Relevance 0.19 Pain Relevance 0
Following four days of recovery, one gene, ovotransferrin, was significantly upregulated in the retina–RPE–choroid of recovering eyes as compared with contralateral control eyes.
Positive_regulation (upregulated) of RPE in eyes
14) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2671582 Disease Relevance 0.29 Pain Relevance 0
It should be noted that the chick gene microarray used in the present study represented 4,000 genes with an emphasis on genes expressed in the chicken immune system and therefore does not provide a comprehensive list of all changes in gene expression that might be occurring in the retina, RPE, or choroid during the recovery from induced myopia.
Positive_regulation (occurring) of RPE in retina associated with myopia
15) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2671582 Disease Relevance 0.33 Pain Relevance 0
Twenty-four hours after LPS-injection, the average level of MCP-1 in the RPE-choroid complex of the EIU animals was upregulated (519.0±57.3 pg/mg, n=8, p<0.01) compared with that of the controls (8.6±2 pg/mg, n=4; Figure 4A).
Positive_regulation (upregulated) of RPE-choroid in choroid associated with uveitis
16) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.81 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox