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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.35
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox9) signal transduction (Sox9) nucleus (Sox9)
extracellular matrix organization (Sox9) protein complex assembly (Sox9) DNA binding (Sox9)
Sox9 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 68.72 Quite High
methotrexate 17 53.68 Quite High
Paracetamol 2 49.48 Quite Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 3 100.00 Very High Very High Very High
Osteoporosis 1 81.04 Quite High
Apoptosis 28 64.24 Quite High
Targeted Disruption 24 56.92 Quite High
Necrosis 1 50.48 Quite High
Mucositis 14 50.00 Quite Low
Hepatotoxicity 1 22.28 Low Low
Wound Healing 15 5.00 Very Low Very Low Very Low
Obesity 14 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the decrease in BMP4 might also indirectly cause the observed decrease in SI expression, because inhibition of BMP4 stimulates Wnt signaling, and Wnt signaling itself induces SOX9, a negative regulator of Cdx2, which is a SI transcriptional activator [3, 10, 39].
Positive_regulation (induces) of SOX9
1) Confidence 0.43 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0.03
Furthermore, significantly higher levels of Sox9, a chondrogenic transcription factor, were expressed in PTSCs and ATSCs than in control cells (Figure 3A, B, columns 5 and 6).
Positive_regulation (levels) of Sox9
2) Confidence 0.12 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2822826 Disease Relevance 0.08 Pain Relevance 0
Although NCoA6 was initially cloned as coactivator protein for NRs, its detailed characterization by a number of laboratories has uncovered its potential to enhance the activity of a wide variety of other transcription factors including c-Fos, c-Jun, CREB, NF-kB, ATF-2, heat shock factors, E2F-1, SRF, and Rb, p53 and Sox9 [Goo et al., 2004; Hong et al., 2004a; Hong et al., 2004b; Ko et al., 2000; Kong et al., 2003; Lee et al., 1999; Lee et al., 2000; Mahajan et al., 2007; Mahajan et al., 2002; Mahajan and Samuels, 2000; Mahajan and Samuels, 2005].
Positive_regulation (enhance) of Sox9 associated with shock
3) Confidence 0.11 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.27 Pain Relevance 0.03

General Comments

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