INT210243

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.55
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4)
growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)
Anatomy Link Frequency
stem cells 1
Bmp4 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 119 73.20 Quite High
vincristine 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 7 92.28 High High
Apoptosis 70 81.48 Quite High
Mucositis 98 75.00 Quite High
Frailty 49 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 7 5.00 Very Low Very Low Very Low
Solid Tumor 7 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Leukemia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the decrease in BMP4 might also indirectly cause the observed decrease in SI expression, because inhibition of BMP4 stimulates Wnt signaling, and Wnt signaling itself induces SOX9, a negative regulator of Cdx2, which is a SI transcriptional activator [3, 10, 39].
Negative_regulation (decrease) of BMP4
1) Confidence 0.55 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0
At day 2, this decrease in BMP4 expression level progressed and was almost significant (P=0.05) in comparison to the control level.
Negative_regulation (decrease) of BMP4
2) Confidence 0.55 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.09 Pain Relevance 0.04
Thus, the decrease in BMP4 might result in a decrease in Cdx2 and HNF-1?
Negative_regulation (decrease) of BMP4
3) Confidence 0.55 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0.04
Furthermore, the decrease in BMP4 might also indirectly cause the observed decrease in SI expression, because inhibition of BMP4 stimulates Wnt signaling, and Wnt signaling itself induces SOX9, a negative regulator of Cdx2, which is a SI transcriptional activator [3, 10, 39].
Negative_regulation (inhibition) of BMP4
4) Confidence 0.55 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0
At day 7, BMP4 levels were down-regulated, while the levels of the epithelial differentiation markers and TCF4 were normalized again.
Negative_regulation (regulated) of BMP4
5) Confidence 0.41 Published 2007 Journal Dig Dis Sci Section Abstract Doc Link PMC1914222 Disease Relevance 0.23 Pain Relevance 0
At day 7, BMP4 levels were down-regulated, while the levels of the epithelial differentiation markers and TCF4 were normalized again.
Negative_regulation (down) of BMP4
6) Confidence 0.41 Published 2007 Journal Dig Dis Sci Section Abstract Doc Link PMC1914222 Disease Relevance 0.23 Pain Relevance 0
During the regenerative phase, at day 7, BMP4 expression level was down-regulated again, which could be a response to the shortage in number of crypts, since a blockage of BMP4 has been shown to cause stem cells to divide, leading to newly formed crypts [8, 10].
Negative_regulation (blockage) of BMP4 in stem cells
7) Confidence 0.40 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0

General Comments

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