INT210247

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.36
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4)
growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)
Anatomy Link Frequency
ligaments 1
tendons 1
muscle 1
Bmp4 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 92 80.92 Quite High
cva 6 69.72 Quite High
antagonist 6 67.44 Quite High
alcohol 1 66.88 Quite High
spinal inflammation 4 57.72 Quite High
rheumatoid arthritis 4 56.64 Quite High
methotrexate 34 34.48 Quite Low
Inflammation 15 11.64 Low Low
ischemia 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 13 99.84 Very High Very High Very High
Fibrodysplasia Ossificans Progressiva 20 99.16 Very High Very High Very High
Heterotopic Ossification 324 98.60 Very High Very High Very High
Injury 36 98.38 Very High Very High Very High
Apoptosis 20 89.76 High High
Mucositis 28 82.52 Quite High
Cicatrix 1 78.60 Quite High
Gonadal Disease 3 77.12 Quite High
Gastrointestinal Hemorrhage 6 69.72 Quite High
Peptic Ulcer 3 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At day 3, when damage was most severe, BMP4 was increased, which inversely correlated with proliferation, and correlated with epithelial differentiation, as suggested by the recovery of TFF3 expression level.
Positive_regulation (increased) of BMP4
1) Confidence 0.65 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0
During severe damage (day 3), BMP4 levels were significantly increased, which inversely correlated with epithelial proliferation.
Positive_regulation (increased) of BMP4
2) Confidence 0.44 Published 2007 Journal Dig Dis Sci Section Abstract Doc Link PMC1914222 Disease Relevance 0.25 Pain Relevance 0
In turn this suggests that trauma-induced HO depends upon susceptibility determined by other factors—in this case elevated levels of BMP4.
Positive_regulation (elevated) of BMP4 associated with injury and heterotopic ossification
3) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 1.65 Pain Relevance 0.12
BMP-4 in particular has been demonstrated to be elevated in diseases such as fibrodysplasia ossificans progressive (FOP), a disease characterized by the progressive ossification of soft tissue, especially muscle, tendons and ligaments[2,65].
Positive_regulation (elevated) of BMP-4 in ligaments associated with fibrodysplasia ossificans progressiva and disease
4) Confidence 0.23 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2674414 Disease Relevance 0.82 Pain Relevance 0.23
BMP-4 in particular has been demonstrated to be elevated in diseases such as fibrodysplasia ossificans progressive (FOP), a disease characterized by the progressive ossification of soft tissue, especially muscle, tendons and ligaments[2,65].
Positive_regulation (elevated) of BMP-4 in muscle associated with fibrodysplasia ossificans progressiva and disease
5) Confidence 0.08 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2674414 Disease Relevance 0.82 Pain Relevance 0.23
BMP-4 in particular has been demonstrated to be elevated in diseases such as fibrodysplasia ossificans progressive (FOP), a disease characterized by the progressive ossification of soft tissue, especially muscle, tendons and ligaments[2,65].
Positive_regulation (elevated) of BMP-4 in tendons associated with fibrodysplasia ossificans progressiva and disease
6) Confidence 0.08 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2674414 Disease Relevance 0.82 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox