INT210256

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tcf7l2) cytosol (Tcf7l2) nucleoplasm (Tcf7l2)
nucleus (Tcf7l2) DNA binding (Tcf7l2) transcription factor binding (Tcf7l2)
Anatomy Link Frequency
T-cell 1
Tcf7l2 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 17 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 41 100.00 Very High Very High Very High
Apoptosis 10 96.52 Very High Very High Very High
Disease 2 92.56 High High
Genetic Predisposition To Disease 1 91.60 High High
Mucositis 14 89.28 High High
Frailty 7 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 3 5.00 Very Low Very Low Very Low
Metabolic Syndrome 3 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concurrently, T-cell factor-4 (TCF4) levels increased and the epithelial differentiation enhancing factor, bone morphogenic protein-4 (BMP4), decreased.
Positive_regulation (increased) of T-cell factor-4 in T-cell
1) Confidence 0.28 Published 2007 Journal Dig Dis Sci Section Abstract Doc Link PMC1914222 Disease Relevance 0.26 Pain Relevance 0
Five genome-wide association studies have been published since February 2007, increasing the number of confirmed type 2 diabetes susceptibility loci from three (PPARG, KCNJ11, and TCF7L2) to 9 (with the addition of CDKAL1, CDKN2A/B, IGF2BP2, HHEX/IDE, FTO, and SLC30A8) (2).
Positive_regulation (increasing) of TCF7L2 associated with diabetes mellitus
2) Confidence 0.20 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2551631 Disease Relevance 0.98 Pain Relevance 0

General Comments

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