INT210276

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.58
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PMP22) plasma membrane (PMP22)
Anatomy Link Frequency
Schwann cells 4
PMP22 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 8 99.94 Very High Very High Very High
antagonist 6 96.80 Very High Very High Very High
agonist 4 85.04 High High
Inflammation 8 76.56 Quite High
diabetic neuropathy 4 72.16 Quite High
cytokine 2 71.28 Quite High
corticosteroid 10 67.44 Quite High
carpal tunnel syndrome 76 65.12 Quite High
Pain 22 54.88 Quite High
Pain scale 10 53.32 Quite High
Disease Link Frequency Relevance Heat
Disease 6 100.00 Very High Very High Very High
INFLAMMATION 10 76.56 Quite High
Neuropathy 8 76.56 Quite High
Premature Birth 2 75.80 Quite High
Aging 4 72.72 Quite High
Diabetic Neuropathy 4 72.16 Quite High
Injury 6 69.52 Quite High
Carpal Tunnel Syndrome 78 65.12 Quite High
Pressure And Volume Under Development 6 62.96 Quite High
Brain Injury 4 61.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2.9 Mb in size and included the PMP22 gene known to cause CMT1A disease with dosage-specific overexpression of PMP22 (Patel et al. 1992).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PMP22 associated with disease
1) Confidence 0.46 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.26 Pain Relevance 0
2.9 Mb in size and included the PMP22 gene known to cause CMT1A disease with dosage-specific overexpression of PMP22 (Patel et al. 1992).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PMP22 associated with disease
2) Confidence 0.46 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.21 Pain Relevance 0
GABA-A involvement in the expression of PMP22 is confirmed by the finding that in cultured rat Schwann cells a specific GABA antagonist such as bicuculline completely abolishes the stimulatory effect exerted by 5?
Positive_regulation (involvement) of Gene_expression (expression) of PMP22 in Schwann cells associated with gaba and antagonist
3) Confidence 0.34 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2873263 Disease Relevance 0.56 Pain Relevance 0.60
Progesterone modulate the expression of key transcription factors for Schwann cell function, regulate Schwann cell proliferation and promote the expression of myelin proteins involved in the maintenance of myelin multilamellar structure, such as myelin protein zero and peripheral myelin protein 22.
Positive_regulation (promote) of Gene_expression (expression) of myelin protein 22 in Schwann cell
4) Confidence 0.28 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2873263 Disease Relevance 0.54 Pain Relevance 0.28

General Comments

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