INT210278

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RAI1) cytoplasm (RAI1)
RAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3 31.76 Quite Low
aspirin 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 66 100.00 Very High Very High Very High
Syndrome 46 100.00 Very High Very High Very High
Rheumatoid Arthritis 19 100.00 Very High Very High Very High
Neurodegenerative Disease 4 94.24 High High
Nephritis 1 36.08 Quite Low
INFLAMMATION 3 31.76 Quite Low
Chromosome Deletion 2 24.48 Low Low
Adhesions 4 21.12 Low Low
Apoptosis 5 5.72 Low Low
Atherosclerosis 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This resulted in the insertion of the MDLS region into the middle SMS-REP/LCR17pB block, loss of telomeric 17p and part of 17p12 and duplication of the CMT1A region.
Positive_regulation (duplication) of SMS associated with syndrome
1) Confidence 0.42 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.25 Pain Relevance 0
The most significant upregulated RA-inducible gene in CD34+ cells from CAD patients was RAI1, a transcription factor which does not posses a DNA binding domain but likely influences differentiation through complex formation with other proteins mediating chromatin remodeling [28].
Positive_regulation (upregulated) of RAI1 associated with coronary artery disease and rheumatoid arthritis
2) Confidence 0.36 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 1.39 Pain Relevance 0

General Comments

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