INT2103

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Context Info
Confidence 0.77
First Reported 1978
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 3.16
Pain Relevance 23.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neural 3
hypothalamus 2
median eminence 2
brain 1
Lip 1
Rhd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 13 99.92 Very High Very High Very High
Morphine 72 99.80 Very High Very High Very High
narcan 80 99.74 Very High Very High Very High
agonist 60 99.74 Very High Very High Very High
noradrenaline 91 99.52 Very High Very High Very High
opiate 26 99.44 Very High Very High Very High
Potency 13 99.40 Very High Very High Very High
antagonist 99 99.32 Very High Very High Very High
Endogenous opioid 14 99.32 Very High Very High Very High
Enkephalin 8 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatic Fever 16 100.00 Very High Very High Very High
Rheumatic Heart Disease 13 100.00 Very High Very High Very High
Lordosis 6 99.40 Very High Very High Very High
Aging 6 93.96 High High
Myocarditis 3 81.28 Quite High
Chorea 1 81.04 Quite High
INFLAMMATION 9 75.32 Quite High
Urological Neuroanatomy 1 75.00 Quite High
Arthralgia 1 70.48 Quite High
Disease 3 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rats were treated with the opiate agonist, morphine, and the release of luteinizing hormone-releasing hormone (LH-RH) from their hypothalami was studied in vitro.
Localization (release) of LH-RH associated with agonist, opiate and morphine
1) Confidence 0.77 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 0.83
Within 16-24 h after morphine treatment, basal LH-RH release rates were observed to be higher compared to those from hypothalami derived from opiate-naive rats, suggesting that dependence had occurred in the neural mechanisms underlying LH-RH release.
Localization (release) of LH-RH in neural associated with addiction, opiate and morphine
2) Confidence 0.77 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.08
Within 16-24 h after morphine treatment, basal LH-RH release rates were observed to be higher compared to those from hypothalami derived from opiate-naive rats, suggesting that dependence had occurred in the neural mechanisms underlying LH-RH release.
Localization (release) of LH-RH in neural associated with addiction, opiate and morphine
3) Confidence 0.77 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 0.93
Addition of the opioid antagonist naloxone in vitro resulted in a 220% increase in the release of LH-RH by hypothalami exposed to morphine for 48 h in vivo, whereas it caused a 50% reduction in LH-RH release from tissues exposed to morphine for 96 h in vivo.
Localization (release) of LH-RH associated with antagonist, narcan, opioid and morphine
4) Confidence 0.77 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.46
Maintenance of tissues exposed to morphine in vivo in medium containing morphine in vitro did not alter the increased basal release of LH-RH, but because this was significantly greater than control rates, tolerance is not believed to have occurred.
Localization (release) of LH-RH associated with tolerance and morphine
5) Confidence 0.77 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.22
Addition of the opioid antagonist naloxone in vitro resulted in a 220% increase in the release of LH-RH by hypothalami exposed to morphine for 48 h in vivo, whereas it caused a 50% reduction in LH-RH release from tissues exposed to morphine for 96 h in vivo.
Localization (release) of LH-RH associated with antagonist, narcan, opioid and morphine
6) Confidence 0.77 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.48
The present study utilizes an in vitro perifusion paradigm to compare the ability of opiate receptor blockade with naloxone to stimulate LH-RH release from tissue fragments from ovariectomized, estrogen-treated young and middle-aged females.
Localization (release) of LH-RH associated with narcan and opiate
7) Confidence 0.77 Published 1993 Journal Brain Res. Section Abstract Doc Link 8431770 Disease Relevance 0.09 Pain Relevance 0.44
Naloxone stimulated a greater than 50% increase in LH-RH release from most fragments that contained primarily LH-RH axons and terminals and from all tissue fragments that contained the majority of LH-RH cell bodies as well as axons and terminals.
Localization (release) of LH-RH associated with narcan
8) Confidence 0.77 Published 1993 Journal Brain Res. Section Abstract Doc Link 8431770 Disease Relevance 0.09 Pain Relevance 0.54
These data suggest that LH-RH neurosecretion in ovx, estrogen-primed middle-aged female rats remains under the inhibitory influence of endogenous opioid peptides.
Localization (neurosecretion) of LH-RH associated with endogenous opioid
9) Confidence 0.77 Published 1993 Journal Brain Res. Section Abstract Doc Link 8431770 Disease Relevance 0.07 Pain Relevance 0.55
Within 16-24 h after morphine treatment, basal LH-RH release rates were observed to be higher compared to those from hypothalami derived from opiate-naive rats, suggesting that dependence had occurred in the neural mechanisms underlying LH-RH release.
Localization (release) of LH-RH in neural associated with addiction, opiate and morphine
10) Confidence 0.72 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 0.93
Endogenous opioids play a role in the regulation of LH-RH neurosecretion throughout the estrous cycle and during the preovulatory LH surge on proestrus.
Localization (neurosecretion) of LH-RH associated with endogenous opioid
11) Confidence 0.72 Published 1993 Journal Brain Res. Section Abstract Doc Link 8431770 Disease Relevance 0.08 Pain Relevance 0.36
These data suggest that LH-RH neurosecretion in ovx, estrogen-primed middle-aged female rats remains under the inhibitory influence of endogenous opioid peptides.
Localization (neurosecretion) of LH-RH associated with endogenous opioid
12) Confidence 0.72 Published 1993 Journal Brain Res. Section Abstract Doc Link 8431770 Disease Relevance 0.07 Pain Relevance 0.55
Seemingly, hypothalamic LH-RH is released as pulsatile pulses from a releasable pool; this pool is replenished and again LH-RH is discharged in response to constant stimulation by the preoptic brain.
Localization (released) of LH-RH in brain
13) Confidence 0.70 Published 1978 Journal Brain Res. Section Abstract Doc Link 350353 Disease Relevance 0.07 Pain Relevance 0.09
Hypothalamic LH-RH release after acute and chronic treatment with morphine studied in a combined in vivo/in vitro model.
Localization (release) of LH-RH associated with narcan and morphine
14) Confidence 0.67 Published 1988 Journal Brain Res. Section Title Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.13
Although in vitro LH-RH release did not differ in response to naloxone, age-related differences in naloxone's ability to increase serum LH levels in vivo were observed.
Localization (release) of LH-RH associated with narcan
15) Confidence 0.67 Published 1993 Journal Brain Res. Section Abstract Doc Link 8431770 Disease Relevance 0.07 Pain Relevance 0.54
Among seven PGs tested at 10(-6) M, only PGE2, PGE1, PGA2, and 16,16-dimethyl PGE2 significantly enhanced LH-RH secretion. 8-iso PGE2 weakly stimulated LH-RH secretion, whereas PGF2 alpha and PGD2 were ineffective.
Localization (secretion) of LH-RH
16) Confidence 0.66 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.79
A direct correlation existed between the potency of these compounds to modify LH-RH secretion and to inhibit specific [3H]-PGE2 binding to hypothalamic membranes.
Localization (secretion) of LH-RH associated with potency
17) Confidence 0.66 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.70
The effects of some adrenoceptor agonists (10(-5) M) on LH-RH release were tested: only phenylephrine (alpha 1-agonist) stimulated LH-RH release; clonidine (alpha 2 greater than alpha 1-agonist) and isoproterenol (beta-agonist) were ineffective.
Localization (release) of LH-RH associated with agonist and clonidine
18) Confidence 0.66 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.69
When tested alone, no significant effect was obtained on basal LH-RH release with any of the antagonists tested.
Localization (release) of LH-RH associated with antagonist
19) Confidence 0.66 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.84
Noradrenaline (NA) and prostaglandin (PG) E2 produced a dose-related stimulation of luteinizing hormone releasing hormone (LH-RH) release from incubated median eminence of adult male rats, with ED50 values of 6.10(-7) and 8.10(-8) M, respectively.
Localization (release) of LH-RH in median eminence associated with noradrenaline
20) Confidence 0.66 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.53

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