INT210300

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.14
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (ELAVL4) RNA binding (ELAVL4)
Anatomy Link Frequency
T cells 6
neurons 1
ELAVL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 84 95.52 Very High Very High Very High
Central nervous system 30 84.88 Quite High
anesthesia 7 74.68 Quite High
Inflammation 7 70.32 Quite High
addiction 7 39.84 Quite Low
Neuritis 6 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 84 99.68 Very High Very High Very High
Syndrome 245 99.04 Very High Very High Very High
Neuroblastoma 18 98.64 Very High Very High Very High
Skin Cancer 14 94.88 High High
Disease 47 93.64 High High
Cancer 99 92.56 High High
Cytomegalovirus Infection 140 91.76 High High
Necrosis 14 78.00 Quite High
Neurological Disease 10 74.00 Quite High
INFLAMMATION 7 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In parallel, male flies carrying the driver elavc155-Gal4 on their X chromosome were crossed to wild type (Oregon-R) females and the resultant F1, carrying only the elavc155-Gal4 driver served as control

Special fly feeding

Gene_expression (carrying) of elav
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978097 Disease Relevance 0.09 Pain Relevance 0
Consistent expression of HuD in all SCLC suggests that HuD plays a central role in triggering the immune response [15, 17].
Gene_expression (expression) of HuD associated with small cell lung cancer
2) Confidence 0.56 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 1.26 Pain Relevance 0.10
Despite a multifaceted approach mainly geared towards the detection of HuD-reactive CD8+ T cells and, to a somewhat lesser extent, CD4+ T cells, no such cells were detected in the blood of Hu-PNS patients and controls.


Gene_expression (detection) of HuD in T cells associated with syndrome
3) Confidence 0.49 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.78 Pain Relevance 0.04
The use of co-stimulatory antibodies in combination with HuDmix did not result in the detection of HuD-specific T-cell reactivity (not shown).
Gene_expression (detection) of HuD in T-cell
4) Confidence 0.49 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.57 Pain Relevance 0.12
In conclusion, we were unable to detect HuD-specific T cells in a large cohort of Hu-PNS patients and controls.
Neg (unable) Gene_expression (detect) of HuD in T cells associated with syndrome
5) Confidence 0.49 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.76 Pain Relevance 0.04
Detection of HuD-specific CD8+ T cells using Class-I HLA multimers
Gene_expression (Detection) of HuD in T cells
6) Confidence 0.49 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.15 Pain Relevance 0.12
Analysis of HuD-specific CD8+ T cells using Class-I HLA multimers
Gene_expression (Analysis) of HuD in T cells
7) Confidence 0.49 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.85 Pain Relevance 0
With that criterion, 3 PNS, 2 SCLC and 4 HC would have been classified as HuD T-cell responders in our study.
Gene_expression (responders) of HuD in T-cell associated with syndrome and small cell lung cancer
8) Confidence 0.49 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.50 Pain Relevance 0.06
The expression of HuB and HuD has been demonstrated in several neuroblastoma cell lines [54].
Gene_expression (expression) of HuD associated with neuroblastoma
9) Confidence 0.10 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.17 Pain Relevance 0
Among the ARE-binding proteins the ELAV family is of interest since three members (HuB, HuC, HuD) out of four are selectively expressed in neurons and display a stabilizing effect on target mRNAs.
Gene_expression (expressed) of HuD in neurons
10) Confidence 0.08 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0 Pain Relevance 0

General Comments

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