INT210326

Context Info Confidence 0.48 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 10 Disease Relevance 4.27 Pain Relevance 6.26

endoplasmic reticulum (DDOST) translation (DDOST) protein complex (DDOST)

DDOST (Homo sapiens)

Pain Link Frequency Relevance Heat Buprenorphine 364 99.00 drug abuse 55 98.96 addiction 157 98.52 Opioid 212 97.92 cannabis 5 97.74 withdrawal 17 97.60 Antihistamine 2 97.28 methadone 324 97.04 anticonvulsant 2 96.16 narcan 168 91.76

Disease Link Frequency Relevance Heat Cognitive Disorder 108 99.12 Communicable Diseases 25 99.08 Drug Dependence 67 98.96 Death 30 98.64 Opiate Addiction 133 98.52 Substance Withdrawal Syndrome 4 97.96 Hepatitis C Virus Infection 34 92.16 Infection 19 91.84 Acquired Immune Deficiency Syndrome Or Hiv Infection 66 86.88 Confusion 2 83.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OST has also been associated with a reduced risk for prisoner death.

OST Binding (associated) of associated with death

1) Confidence 0.48 Published 2010 Journal Harm Reduct J Section Body Doc Link PMC2918585 Disease Relevance 0.60 Pain Relevance 0.17

Positive prisoner-centred outcomes associated with OST include reduced rates of drug abuse and infectious diseases.

OST Binding (associated) of associated with drug abuse and communicable diseases

2) Confidence 0.42 Published 2010 Journal Harm Reduct J Section Body Doc Link PMC2918585 Disease Relevance 0.76 Pain Relevance 0.58

The possible interactions of OST medications with these medications warrant further studies with larger sample sizes.

OST Binding (interactions) of

3) Confidence 0.39 Published 2009 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2676265 Disease Relevance 0.33 Pain Relevance 1.41

OST in prison has also been associated with reduced rates of infectious disease.

OST Binding (associated) of associated with communicable diseases

4) Confidence 0.32 Published 2010 Journal Harm Reduct J Section Body Doc Link PMC2918585 Disease Relevance 0.72 Pain Relevance 0.56

OST is recognised as one of the most effective treatment options for opioid dependence [34].

OST Binding (recognised) of associated with addiction and opioid

5) Confidence 0.32 Published 2010 Journal Harm Reduct J Section Body Doc Link PMC2918585 Disease Relevance 0.51 Pain Relevance 0.59

Most of the inmates were on remand and overall 7.8% (N = 870) were receiving OST, 81.5% with high dosage buprenorphine (N = 709) and 18.5% (N = 161) with methadone.

OST Binding (receiving) of associated with methadone and buprenorphine

6) Confidence 0.32 Published 2008 Journal Harm Reduct J Section Body Doc Link PMC2430551 Disease Relevance 0 Pain Relevance 0.66

Implementing OST in prisons is also associated with improvement in inmate manageability and prison safety; total institutional charges for prisoners enrolled in MMT are lower than for prisoners not enrolled in MMT [21].

OST Binding (associated) of

7) Confidence 0.31 Published 2010 Journal Harm Reduct J Section Body Doc Link PMC2918585 Disease Relevance 0.08 Pain Relevance 0.24

Thus, these substances such as cannabis may explain the differences between the studied OST patient groups only if they have long-term effects and they interact differently with the OST drugs.

OST Binding (interact) of associated with cannabis

8) Confidence 0.30 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1914339 Disease Relevance 0.50 Pain Relevance 0.61

It is possible that this is associated with OST drugs and BZDs given legally to the OD patients.

OST Binding (associated) of associated with addiction

9) Confidence 0.29 Published 2009 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2676265 Disease Relevance 0.44 Pain Relevance 0.30

The interactions of OST medications and all these medications warrant for further studies.

OST Binding (interactions) of

10) Confidence 0.23 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1914339 Disease Relevance 0.33 Pain Relevance 1.15

General Comments

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