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Context Info
Confidence 0.45
First Reported 1982
Last Reported 1997
Negated 0
Speculated 3
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.21
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
hypothalamus 2
arcuate nucleus 2
pituitary 2
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 3 100.00 Very High Very High Very High
Opioid 4 99.50 Very High Very High Very High
Clonidine 23 99.44 Very High Very High Very High
agonist 4 97.96 Very High Very High Very High
Morphine 4 95.56 Very High Very High Very High
MU agonist 1 95.20 Very High Very High Very High
narcan 3 94.08 High High
antagonist 1 93.72 High High
Glutamate 6 93.12 High High
Somatostatin 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Body Weight 1 91.20 High High
Heart Rate Under Development 3 65.76 Quite High
Depression 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we investigated the mechanisms of this opioid effect and examined the effects of other neurotransmitter substances on modulation of pituitary GnRH-R.
Spec (examined) Regulation (effects) of Spec (examined) Regulation (modulation) of GnRH-R in pituitary associated with neurotransmitter and opioid
1) Confidence 0.45 Published 1985 Journal Endocrinology Section Abstract Doc Link 2857637 Disease Relevance 0 Pain Relevance 0.88
Down-regulation of alpha 2-adrenoceptors involved in growth hormone control in the hypothalamus of infant rats receiving short-term clonidine administration.
Regulation (involved) of Regulation (control) of growth hormone in hypothalamus associated with clonidine
2) Confidence 0.17 Published 1990 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 2162745 Disease Relevance 0.12 Pain Relevance 0.79
The aim of this study was to investigate further the possible role of nerve cells of the arcuate nucleus in the regulation of growth hormone (GH) and prolactin (PRL) secretion.
Spec (possible) Regulation (role) of Regulation (regulation) of growth hormone in arcuate nucleus
3) Confidence 0.17 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 7145019 Disease Relevance 0.09 Pain Relevance 0.36
This study was designed to examine the effect of fetal ethanol (ETOH) exposure on the sensitivity of the hypothalamic-growth hormone (GH) axis to clonidine (an alpha 2-adrenoreceptor agonist) stimulation and GH feedback.
Spec (examine) Regulation (effect) of Regulation (sensitivity) of hypothalamic-growth hormone associated with agonist and clonidine
4) Confidence 0.05 Published 1997 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9267532 Disease Relevance 0 Pain Relevance 0.26

General Comments

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