INT210390

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.78
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFA) extracellular region (PDGFA) embryo development (PDGFA)
cell-cell signaling (PDGFA)
Anatomy Link Frequency
platelet 2
MCF 7 1
Plasma 1
livers 1
hepatocytes 1
PDGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 31 98.96 Very High Very High Very High
cytokine 51 95.36 Very High Very High Very High
Pain 17 90.44 High High
Inflammatory marker 18 82.56 Quite High
Inflammation 110 82.24 Quite High
fibrosis 39 81.04 Quite High
chemokine 7 66.64 Quite High
Inflammatory response 22 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Bioavailability 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 51 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 34 100.00 Very High Very High Very High
Tricuspid Valve Insufficiency 153 99.76 Very High Very High Very High
Sickle Cell Anemia 189 99.68 Very High Very High Very High
Cirrhosis 265 97.72 Very High Very High Very High
Fibrosis 53 97.40 Very High Very High Very High
Hypoxia 35 97.12 Very High Very High Very High
Gastrointestinal Stromal Tumor 104 92.88 High High
Adhesions 10 91.36 High High
Necrosis 46 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Imatinib is a selective tyrosine kinase inhibitor which binds KIT, Bcr-Abl, PDGFA/PDGFB.
PDGFA Binding (binds) of
1) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.91 Pain Relevance 0
However, the pathway analysis lends support to the finding of contrasting associations of VEGF and PDGF with tricuspid regurgitation velocity.
PDGF Binding (associations) of associated with tricuspid valve insufficiency
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 1.10 Pain Relevance 0
Plasma concentrations of PDGF-BB (medians of 0.3 ng/ml versus 0.4 ng/ml, P?
PDGF Binding (concentrations) of in Plasma
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 0.67 Pain Relevance 0.07
In contrast, Figure 2b–d shows that the adjusted mean values for PDGF, interleukin-6 and hemolytic index were higher with tricuspid regurgitation velocity ?
PDGF Binding (index) of associated with tricuspid valve insufficiency
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 0.73 Pain Relevance 0.04
This is because, as PS-ODNS are more negatively charged as compared to phosphodiester ODNs, their polyanionic nature enhances their affinity for proteins, such as heparin-binding proteins, cell surface proteins, viral protein CD4, HIV glycoprotein 120, epidermal growth factor receptor (EGFR), platelet-derived growth factor (PDGF) and certain isoforms of protein kinase C (PKC), resulting in non-specific side effects.
platelet-derived growth factor Binding (affinity) of in platelet associated with kinase c and acquired immune deficiency syndrome or hiv infection
5) Confidence 0.17 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.17 Pain Relevance 0.10
None of EGF, FGF and PDGF had a significant effect on ADAMTS-1 mRNA expression (Fig. 6A), but each induced significant decreases in ADAMTS-5 mRNA levels (P < 0.01, except for PDGF P < 0.05), which were maintained over 48 h (Fig. 6C).
PDGF Neg (None) Binding (None) of
6) Confidence 0.16 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.14
This is because, as PS-ODNS are more negatively charged as compared to phosphodiester ODNs, their polyanionic nature enhances their affinity for proteins, such as heparin-binding proteins, cell surface proteins, viral protein CD4, HIV glycoprotein 120, epidermal growth factor receptor (EGFR), platelet-derived growth factor (PDGF) and certain isoforms of protein kinase C (PKC), resulting in non-specific side effects.
PDGF Binding (affinity) of in platelet associated with kinase c and acquired immune deficiency syndrome or hiv infection
7) Confidence 0.15 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.17 Pain Relevance 0.10
This peculiar effect of HNE and HAKs is transient, with sensitivity to PDGF-BB being recovered within 48 hours and associated with increased expression of PDGF-?
PDGF-BB Binding (sensitivity) of
8) Confidence 0.09 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.07 Pain Relevance 0
In contrast, PDGF BB does not significantly alter cell migration of MCF 7 breast cancer cells, but imatinib reduces their migration significantly at 48 hours and as well at 72 hours of incubation.
PDGF Binding (migration) of in MCF 7 associated with breast cancer
9) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.47 Pain Relevance 0
The carrier pPBHSA competitively inhibited the binding of PDGF-BB to its receptor, and in vivo preferentially homed to the HSC in fibrotic rat livers with minor uptake in hepatocytes (5).
PDGF-BB Binding (binding) of in livers associated with fibrosis and cirrhosis
10) Confidence 0.03 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.60 Pain Relevance 0.13
1, PDGF, and MMPs, highlighting the coordinated cell-to-cell and cell-to-environment interactions [29].
PDGF Binding (interactions) of
11) Confidence 0.02 Published 2007 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570564 Disease Relevance 0.46 Pain Relevance 0.03
It is likely that the pPB-conjugate, as also proposed for the carrier pPBHSA (5), follows a similar distribution pattern as the growth factor PDGF-BB, which is taken up by hepatocytes after opsonization by ?
PDGF-BB Binding (taken) of in hepatocytes
12) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.45 Pain Relevance 0.03

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