INT210392

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 11.41
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFA) extracellular region (PDGFA) embryo development (PDGFA)
cell-cell signaling (PDGFA)
Anatomy Link Frequency
platelet 3
macrophages 1
hepatocytes 1
granulation 1
mast cells 1
PDGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 273 100.00 Very High Very High Very High
Inflammatory response 97 100.00 Very High Very High Very High
cytokine 116 99.66 Very High Very High Very High
Inflammatory mediators 6 99.66 Very High Very High Very High
ischemia 15 71.36 Quite High
peripheral neuropathy 6 67.64 Quite High
fibrosis 33 64.36 Quite High
Osteoarthritis 17 55.92 Quite High
antagonist 11 52.16 Quite High
headache 5 48.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 369 100.00 Very High Very High Very High
Injury 311 100.00 Very High Very High Very High
Adhesions 55 100.00 Very High Very High Very High
Esophageal Cancer 26 98.62 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 98.40 Very High Very High Very High
Hematoma 2 98.28 Very High Very High Very High
Tricuspid Valve Insufficiency 51 97.88 Very High Very High Very High
Adult Respiratory Distress Syndrome 40 97.86 Very High Very High Very High
Ovarian Cancer 100 97.84 Very High Very High Very High
Disseminated Intravascular Coagulation 2 97.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One study utilizing a rat incisional wound model showed increased inflammatory response, wound cellularity, granulation tissue formation, neovascularization, and epithelialization in PDGF-treated wounds the over control wounds.
Regulation (response) of PDGF in granulation associated with inflammatory response and injury
1) Confidence 0.36 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727777 Disease Relevance 1.71 Pain Relevance 0.12
In contrast, Figure 2b–d shows that the adjusted mean values for PDGF, interleukin-6 and hemolytic index were higher with tricuspid regurgitation velocity ?
Regulation (values) of PDGF associated with tricuspid valve insufficiency
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 0.73 Pain Relevance 0.04
Motesanib is a small molecule tyrosine kinase inhibitor of VEGF that targets VEGFR 1, 2, 3 and PDGF that has been evaluated in preclinical models in combination with either tamoxifen or docetaxel and was shown to have potential use in breast cancer.[68] A large phase II clinical trial is ongoing evaluating motesanib and paclitaxel in the treatment of breast cancer).[47]
Regulation (evaluated) of PDGF associated with breast cancer
3) Confidence 0.19 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 0.83 Pain Relevance 0.03
In the present study, we examined 11 proinflammatory genes in patients receiving therapy in the ICU following surgery for esophageal cancer: matrix metallopeptidase 9 (MMP9), which reflects the activity of neutrophils and correlates with survival in patients with esophageal cancer [12-14]; early growth response 1 (EGR1), as a transcriptional regulator in ALI [15-17]; high-mobility group box 1 (HMGB1), as a candidate proinflammatory factor predicting the prognosis of SIRS [18-20]; mucin1 (MUC1), as both an independent predictor for intravascular coagulation in ARDS and a biomarker for esophageal cancer [21-23]; nicotinamide phosphoribosyltransferase (NAMPT/PBEF1), as a regulator in new inflammatory networks [24-27]; platelet-derived growth factor alpha polypeptide (PDGFA), which is involved in alveolar septal formation [28-30]; transforming growth factor beta 1 (TGF-?
Regulation (regulator) of platelet-derived growth factor alpha polypeptide in platelet associated with inflammation, systemic inflammatory response syndrome, disseminated intravascular coagulation, adult respiratory distress syndrome and esophageal cancer
4) Confidence 0.19 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 1.52 Pain Relevance 0.08
In the present study, we examined 11 proinflammatory genes in patients receiving therapy in the ICU following surgery for esophageal cancer: matrix metallopeptidase 9 (MMP9), which reflects the activity of neutrophils and correlates with survival in patients with esophageal cancer [12-14]; early growth response 1 (EGR1), as a transcriptional regulator in ALI [15-17]; high-mobility group box 1 (HMGB1), as a candidate proinflammatory factor predicting the prognosis of SIRS [18-20]; mucin1 (MUC1), as both an independent predictor for intravascular coagulation in ARDS and a biomarker for esophageal cancer [21-23]; nicotinamide phosphoribosyltransferase (NAMPT/PBEF1), as a regulator in new inflammatory networks [24-27]; platelet-derived growth factor alpha polypeptide (PDGFA), which is involved in alveolar septal formation [28-30]; transforming growth factor beta 1 (TGF-?
Regulation (regulator) of PDGFA in platelet associated with inflammation, systemic inflammatory response syndrome, disseminated intravascular coagulation, adult respiratory distress syndrome and esophageal cancer
5) Confidence 0.19 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 1.53 Pain Relevance 0.08
Targeting the PDGF/PDGFR axis alone or in combination with classical chemotherapy is not very effective in the clinical setting.
Regulation (Targeting) of PDGF
6) Confidence 0.12 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.88 Pain Relevance 0
Inflammatory cells, such as activated macrophages and mast cells, can produce inflammatory mediators that promote up-regulation of PDGF receptors on mesenchymal cells.
Regulation (regulation) of PDGF in mast cells associated with inflammatory mediators and inflammation
7) Confidence 0.12 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2945962 Disease Relevance 1.10 Pain Relevance 0.26
The fibrin network within the hematoma traps platelets that, in turn, release various bioactive factors, including platelet derived growth factor (PDGF) and transforming growth factor (TGF)-?
Regulation (derived) of PDGF in platelets associated with hematoma and tumor necrosis factor receptor-associated periodic syndrome
8) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.69 Pain Relevance 0.06
KSHV induced COX-2/PGE2 also regulates VEGF-A and VEGF-C (Figure 6), the multifunctional potent immunosuppressive cytokines that profoundly regulate cell growth, adhesion, angiogenesis, proliferation and differentiation, as well as FGF-4, PDGF, TGF-?
Regulation (regulate) of PDGF associated with herpes simplex virus, adhesions and cytokine
9) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.83 Pain Relevance 0.17
Inflammatory cells, such as activated macrophages and mast cells, can produce inflammatory mediators that promote up-regulation of PDGF receptors on mesenchymal cells.
Regulation (regulation) of PDGF in macrophages associated with inflammatory mediators and inflammation
10) Confidence 0.04 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2945962 Disease Relevance 1.10 Pain Relevance 0.26
It is likely that the pPB-conjugate, as also proposed for the carrier pPBHSA (5), follows a similar distribution pattern as the growth factor PDGF-BB, which is taken up by hepatocytes after opsonization by ?
Regulation (follows) of PDGF-BB in hepatocytes
11) Confidence 0.03 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.51 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox