INT210393

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.26
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.29
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (IGF2R) signal transduction (IGF2R) nucleus (IGF2R)
cytoplasm (IGF2R)
Anatomy Link Frequency
liver 2
IGF2R (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 10 98.24 Very High Very High Very High
cytokine 1 73.44 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Enkephalin 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 110 99.36 Very High Very High Very High
Fibrosis 8 95.60 Very High Very High Very High
Disease 47 72.44 Quite High
Injury 4 52.00 Quite High
Apoptosis 20 47.28 Quite Low
Liver Disease 1 17.44 Low Low
Atherosclerosis 17 5.00 Very Low Very Low Very Low
Age-related Macular Degeneration 10 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to its natural relevance to lysosomal delivery, traditionally only M6P was used for ERT via M6P/IGF2R.
Positive_regulation (relevance) of Gene_expression (used) of IGF2R
1) Confidence 0.26 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0 Pain Relevance 0
The expression of these M6P/IGFII receptors increases as a result of HSC activation during liver fibrosis (11) enabling selective accumulation of M6PHSA in HSC of fibrotic rats (4).
Positive_regulation (increases) of Gene_expression (expression) of M6P/IGFII in liver associated with fibrosis and cirrhosis
2) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.29 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox