INT210399

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 17.10
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (IGF2R) signal transduction (IGF2R) nucleus (IGF2R)
cytoplasm (IGF2R)
Anatomy Link Frequency
liver 3
TFK-1 2
hepatocyte 1
IGF2R (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 57 97.68 Very High Very High Very High
fibrosis 60 97.44 Very High Very High Very High
palliative 24 91.56 High High
adenocard 76 89.40 High High
antagonist 26 86.04 High High
Dopamine 166 83.56 Quite High
ischemia 48 77.40 Quite High
midbrain 40 74.68 Quite High
cytokine 7 71.84 Quite High
imagery 76 71.68 Quite High
Disease Link Frequency Relevance Heat
Microsatellite Instability 94 99.96 Very High Very High Very High
Fibrosis 48 99.68 Very High Very High Very High
Cirrhosis 660 99.56 Very High Very High Very High
Endometrial Cancer 306 99.44 Very High Very High Very High
Cholangiocarcinoma 444 99.22 Very High Very High Very High
Alveolar Rhabdomyosarcoma 40 98.96 Very High Very High Very High
Coronary Artery Disease 236 98.62 Very High Very High Very High
Cancer 384 98.36 Very High Very High Very High
Cicatrix 8 98.26 Very High Very High Very High
Disease 164 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RII), BAX, insulin-like growth factor II receptor (IGFIIR), MSH3, MSH6, caspase-5, and PTEN may promote MSI-positive endometrial carcinoma [8, 9].
Gene_expression (promote) of IGFIIR associated with microsatellite instability and endometrial cancer
1) Confidence 0.65 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.71 Pain Relevance 0
In our experiments IGF2R mRNA and protein expression was found in EGI-1, HuH28, OZ and TFK-1 with all methods applied.
Gene_expression (expression) of IGF2R mRNA in TFK-1
2) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.33 Pain Relevance 0.04
EGFR, HGFR, IGF1R, IGF2R and VEGFR1 were detected in all four cell lines (figure 2B).
Gene_expression (detected) of IGF2R
3) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 0.47 Pain Relevance 0
Therefore, the aim of this study was to determine the expression of EGFR, IGF1R, IGF2R, HGFR and VEGFR1-3 in four human CC cell lines.
Spec (determine) Gene_expression (expression) of IGF2R associated with cholangiocarcinoma
4) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.07 Pain Relevance 0
The CC cell lines investigated in this study express EGFR, HGFR and IGF2R.
Spec (investigated) Gene_expression (express) of IGF2R associated with cholangiocarcinoma
5) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 0.98 Pain Relevance 0
Expression of EGFR (epithelial growth factor receptor), HGFR (hepatocyte growth factor receptor) IGF1R (insulin-like growth factor 1 receptor), IGF2R (insulin-like growth factor 2 receptor) and VEGFR1-3 (vascular endothelial growth factor receptor 1-3) were examined in four human CC cell lines (EGI-1, HuH28, OZ and TFK-1).
Gene_expression (Expression) of IGF2R in TFK-1 associated with cholangiocarcinoma
6) Confidence 0.37 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2896958 Disease Relevance 0.84 Pain Relevance 0.14
The IGF2 receptor (IGF2R) was expressed in undifferentiated hESC.
Gene_expression (expressed) of IGF2R
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.23
IGF2R expression was, however, negligible in hESC differentiated as EBs for three weeks [31], or differentiated on PA6 cells.
Gene_expression (expression) of IGF2R
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.17
EGFR, HGFR, and IGF2R were stained by the standard ABC procedure.
Gene_expression (stained) of IGF2R
9) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 0 Pain Relevance 0
RII), BAX, insulin-like growth factor II receptor (IGFIIR), MSH3, MSH6, caspase-5, and PTEN may promote MSI-positive endometrial carcinoma [8, 9].
Gene_expression (promote) of insulin-like growth factor II receptor associated with microsatellite instability and endometrial cancer
10) Confidence 0.36 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.78 Pain Relevance 0
shRNA expression vectors for 7 genes (IGF2R, SREBF2, AKAP11, TFAP2A, LHX3, TPX2 and ING1) were prepared as described [15].
Gene_expression (expression) of IGF2R
11) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958829 Disease Relevance 0.17 Pain Relevance 0
Due to its natural relevance to lysosomal delivery, traditionally only M6P was used for ERT via M6P/IGF2R.
Gene_expression (used) of IGF2R
12) Confidence 0.35 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0 Pain Relevance 0
Thus, GILT might a priori seem to constitute an acceptable route to deliver xenoenzymes for medical bioremediation to M6P/IGF2R presenting cells.
Gene_expression (presenting) of IGF2R
13) Confidence 0.35 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.16 Pain Relevance 0
IGF-II receptor expression has been demonstrated on RMS cell lines [17–19].
Gene_expression (expression) of IGF-II receptor associated with alveolar rhabdomyosarcoma
14) Confidence 0.32 Published 2010 Journal Pediatr Radiol Section Body Doc Link PMC2895865 Disease Relevance 1.22 Pain Relevance 0
We believe that it is important for each centre to define its own MPRi range, given the impact of many variables, such as contrast dose, stress technique and sequence variations on outcome measures.
Gene_expression (range) of MPRi associated with stress
15) Confidence 0.15 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914773 Disease Relevance 1.01 Pain Relevance 0.14
In contrast, we demonstrated improved reproducibility with an MPRi CoV of 19%, 18%, 19% and 26% for global, LAD-, Cx- and RCA-territory, respectively.
Gene_expression (reproducibility) of MPRi CoV
16) Confidence 0.15 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914773 Disease Relevance 0.40 Pain Relevance 0.11
There was no difference in MPRi reproducibility between case and control groups (p = 0.821).


Gene_expression (reproducibility) of MPRi
17) Confidence 0.15 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914773 Disease Relevance 0.37 Pain Relevance 0.03
However, despite the presence of moderate scar burden in the CAD compared with control group, there was no significant difference in MPRi reproducibility between the two groups (p = 0.850).
Gene_expression (reproducibility) of MPRi associated with cicatrix and coronary artery disease
18) Confidence 0.15 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914773 Disease Relevance 1.07 Pain Relevance 0.04
receptor compared to the expression of the M6P/IGFII receptor makes our carrier with the PDGF receptor-recognizing peptides, pPBHSA, the most attractive candidate for application in the human situation.
Gene_expression (expression) of M6P/IGFII
19) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.47 Pain Relevance 0
Fig. 5Immunohistochemical detection of M6P/IGFII-receptor (a, b and c) and PDGF-?
Gene_expression (detection) of M6P/IGFII
20) Confidence 0.02 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.60 Pain Relevance 0.10

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