INT2104

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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 0.38
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
PIT 4
brain 2
neural 2
median eminence 1
iris 1
Rhd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 14 99.84 Very High Very High Very High
Morphine 27 99.64 Very High Very High Very High
narcan 12 99.42 Very High Very High Very High
antagonist 17 99.24 Very High Very High Very High
Opioid 12 99.02 Very High Very High Very High
anesthesia 8 97.72 Very High Very High Very High
opiate 6 96.96 Very High Very High Very High
tolerance 3 95.76 Very High Very High Very High
addiction 3 95.56 Very High Very High Very High
Deafferentation 2 94.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 78.24 Quite High
Urological Neuroanatomy 3 75.00 Quite High
Ocular & Orbital Inflammation 6 5.00 Very Low Very Low Very Low
Uveitis 3 5.00 Very Low Very Low Very Low
Eye Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adrenoceptor antagonists (10(-6) M) were also tested: prazosin (alpha 1-antagonist) and phentolamine (alpha 1/alpha 2-antagonist) almost completely suppressed the enhanced release of LH-RH induced by NA.
Positive_regulation (induced) of LH-RH associated with antagonist and noradrenaline
1) Confidence 0.57 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.83
Within 16-24 h after morphine treatment, basal LH-RH release rates were observed to be higher compared to those from hypothalami derived from opiate-naive rats, suggesting that dependence had occurred in the neural mechanisms underlying LH-RH release.
Positive_regulation (rates) of LH-RH in neural associated with addiction, opiate and morphine
2) Confidence 0.48 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 0.93
Within 16-24 h after morphine treatment, basal LH-RH release rates were observed to be higher compared to those from hypothalami derived from opiate-naive rats, suggesting that dependence had occurred in the neural mechanisms underlying LH-RH release.
Positive_regulation (rates) of LH-RH in neural associated with addiction, opiate and morphine
3) Confidence 0.48 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 0.93
Addition of the opioid antagonist naloxone in vitro resulted in a 220% increase in the release of LH-RH by hypothalami exposed to morphine for 48 h in vivo, whereas it caused a 50% reduction in LH-RH release from tissues exposed to morphine for 96 h in vivo.
Positive_regulation (increase) of LH-RH associated with antagonist, narcan, opioid and morphine
4) Confidence 0.45 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.47
Seemingly, hypothalamic LH-RH is released as pulsatile pulses from a releasable pool; this pool is replenished and again LH-RH is discharged in response to constant stimulation by the preoptic brain.
Positive_regulation (discharged) of LH-RH in brain
5) Confidence 0.44 Published 1978 Journal Brain Res. Section Abstract Doc Link 350353 Disease Relevance 0.07 Pain Relevance 0.08
Seemingly, hypothalamic LH-RH is released as pulsatile pulses from a releasable pool; this pool is replenished and again LH-RH is discharged in response to constant stimulation by the preoptic brain.
Positive_regulation (discharged) of LH-RH in brain
6) Confidence 0.44 Published 1978 Journal Brain Res. Section Abstract Doc Link 350353 Disease Relevance 0.07 Pain Relevance 0.08
In conclusion, these results suggest that the stimulation of LH-RH from median eminence induced by NA and PGE2 involves the activation of an alpha 1-adrenergic receptor and a PGE2 receptor, respectively.
Positive_regulation (stimulation) of LH-RH in median eminence associated with noradrenaline
7) Confidence 0.38 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.66
In the same animals within 15 min poststimulation, MBH-LH-RH increased from the basal concentrations noted after pentobarbital anesthesia to elevated levels comparable to those observed throughout estrus, diestrus and on proestrous morning.
Positive_regulation (increased) of LH-RH associated with anesthesia
8) Confidence 0.35 Published 1978 Journal Brain Res. Section Abstract Doc Link 350353 Disease Relevance 0.07 Pain Relevance 0.10
The enzyme kinetic parameters of the degradation of luteinizing hormone-releasing hormone (LH-RH) and L-cystine-bis-(4-nitroanilide) (Cys-NA) by rat hypothalamic (HYP) and pituitary (PIT) extracts and the effect of various oligopeptides on the rate of LH-RH inactivation were investigated in vitro.
Positive_regulation (inactivation) of LH-RH in pituitary
9) Confidence 0.34 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 375117 Disease Relevance 0 Pain Relevance 0
The enzyme kinetic parameters of the degradation of luteinizing hormone-releasing hormone (LH-RH) and L-cystine-bis-(4-nitroanilide) (Cys-NA) by rat hypothalamic (HYP) and pituitary (PIT) extracts and the effect of various oligopeptides on the rate of LH-RH inactivation were investigated in vitro.
Positive_regulation (inactivation) of LH-RH in pituitary
10) Confidence 0.34 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 375117 Disease Relevance 0 Pain Relevance 0
The 105,000 x g supernatant of 1 rat HYP inactivated 57 microgram LH-RH during a 30 min incubation (Km = 12.4 microM, V max = 2.33 microgram LH-RH/mg protein/min), and of one rat anterior PIT, 48 microgram LH-RH during 30 min of incubation (Km = 12.2 microM, V max = 8.0 microgram LH-RH/mg protein/min).
Positive_regulation (inactivated) of LH-RH in PIT
11) Confidence 0.28 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 375117 Disease Relevance 0 Pain Relevance 0
The 105,000 x g supernatant of 1 rat HYP inactivated 57 microgram LH-RH during a 30 min incubation (Km = 12.4 microM, V max = 2.33 microgram LH-RH/mg protein/min), and of one rat anterior PIT, 48 microgram LH-RH during 30 min of incubation (Km = 12.2 microM, V max = 8.0 microgram LH-RH/mg protein/min).
Positive_regulation (inactivated) of LH-RH in PIT
12) Confidence 0.28 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 375117 Disease Relevance 0 Pain Relevance 0.03
The ether-induced increase in LH-RH content was not affected by pretreatment with pentobarbital; however, the increase was abolished in animals subjected to hypothalamic deafferentation.
Positive_regulation (increase) of LH-RH associated with deafferentation
13) Confidence 0.12 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 785296 Disease Relevance 0 Pain Relevance 0.21
Ether elevated hypothalamic LH-RH 30 min after a 3-min exposure; pentobarbital (30 mg/kgital (30mg/kg) caused no change.
Positive_regulation (elevated) of LH-RH
14) Confidence 0.12 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 785296 Disease Relevance 0 Pain Relevance 0.21
In the anterior segment, no uptake of Rh-Lip by ED1 or OX6-positive cells on the iris was detected (Figure 2A).
Neg (no) Positive_regulation (uptake) of Rh-Lip in iris
15) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.15 Pain Relevance 0.08

General Comments

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