INT210405

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.97
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT1) Golgi apparatus (FUT1) carbohydrate metabolic process (FUT1)
Anatomy Link Frequency
blood 2
FUT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 4 94.32 High High
cINOD 2 93.08 High High
Inflammation 12 89.40 High High
Pain 4 88.84 High High
imagery 6 78.28 Quite High
fibrosis 10 28.80 Quite Low
ischemia 12 5.00 Very Low Very Low Very Low
Versed 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 110 100.00 Very High Very High Very High
Thrombosis 6 94.68 High High
INFLAMMATION 14 92.84 High High
Injury 78 92.12 High High
Coagulation Disorder 2 90.16 High High
Pain 2 88.84 High High
Stress 2 83.44 Quite High
Increased Venous Pressure Under Development 7 78.88 Quite High
Hypoxia 5 70.04 Quite High
Hematological Disease 2 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our studies, we showed that both conjugates were able to effectively reduce the viability of HSC in vitro.
Negative_regulation (reduce) of HSC Binding (viability) of associated with cirrhosis
1) Confidence 0.14 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.65 Pain Relevance 0
In order to neutralize HSC-associated CXCR4, the same protocol was used as reported previously to be effective in blocking the recruitment of BMC [18] or HSC [11,13,18].
Negative_regulation (blocking) of HSC Binding (recruitment) of
2) Confidence 0.08 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.25 Pain Relevance 0.03
Migration of HSC is not prevented by blocking the SDF-1/CXCR4-axis
Negative_regulation (prevented) of HSC Binding (Migration) of
3) Confidence 0.08 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.07 Pain Relevance 0
SDF-1 and CXCR4-neutralizing antibodies inhibit HSC migration in vitro and in vivo
Negative_regulation (inhibit) of HSC Neg (inhibit) Binding (migration) of
4) Confidence 0.08 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.23 Pain Relevance 0.08
Confirming the targets of the small molecules identified in the screen, morpholino oligonucleotide knockdown of cox1 and cox2 reduced HSC formation, an effect that could be rescued by the addition of a long acting derivative of PGE2 (dmPGE2).
Negative_regulation (reduced) of HSC Binding (formation) of
5) Confidence 0.01 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2912314 Disease Relevance 0.43 Pain Relevance 0.27
Likewise, treatment before the onset of blood flow with the NO inihibitor N-nitro-L-arginine methyl ester (L-NAME) reduced HSC formation.
Negative_regulation (reduced) of HSC Binding (formation) of in blood
6) Confidence 0.01 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2912314 Disease Relevance 0.34 Pain Relevance 0

General Comments

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