INT21047

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 4.55
Pain Relevance 8.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
brainstem 2
CEA 2
neurons 2
dorsal 1
oval nucleus 1
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 43 100.00 Very High Very High Very High
Somatostatin 11 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Serotonin 5 100.00 Very High Very High Very High
medulla 21 99.92 Very High Very High Very High
alcohol 2 99.84 Very High Very High Very High
Dopamine 249 99.56 Very High Very High Very High
Lasting pain 4 99.52 Very High Very High Very High
amygdala 25 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 4 100.00 Very High Very High Very High
Aging 8 99.60 Very High Very High Very High
Pain 6 99.52 Very High Very High Very High
Urological Neuroanatomy 39 99.24 Very High Very High Very High
Stress 17 99.20 Very High Very High Very High
Nociception 23 96.04 Very High Very High Very High
Drug Dependence 3 83.16 Quite High
Pressure Volume 2 Under Development 1 78.84 Quite High
Arthritis 2 69.92 Quite High
INFLAMMATION 2 68.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Transcription (expression) of neurotensin in pituitary
1) Confidence 0.69 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
In contrast, cholecystokinin, vasoactive intestinal peptide, substance P, somatostatin, dynorphin-B and neurotensin, although present in some medial septal neurons, were never observed in neurons projecting to the hippocampus.
Transcription (observed) of neurotensin in medial associated with dynorphin, somatostatin, hippocampus, cholecystokinin and substance p
2) Confidence 0.67 Published 1988 Journal Peptides Section Abstract Doc Link 2470066 Disease Relevance 0 Pain Relevance 0.54
Many stressors elicit changes in corticotrophin (CRH), enkephalin (ENK), and neurotensin (NT) mRNA levels within the medial parvocellular region of the paraventricular nucleus of the hypothalamus (mpPVN), and the pattern of changes in mRNA levels appears to depend on the physical characteristics of the stressor.
Transcription (levels) of neurotensin in nucleus associated with enkephalin
3) Confidence 0.67 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10048467 Disease Relevance 0.25 Pain Relevance 0.28
The METH injection caused increases (2.21-fold) in Nts mRNA in the control animals (MC group), confirming previous results, which showed that METH induced a dramatic increase in striatal Nts mRNA levels [41].
Transcription (levels) of Nts
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.11
ASIC, acid-sensing ion channel; ANOVA, analysis of variance; AX, area X around the central canal of the spinal cord; HCl, hydrochloric acid; IG, intragastric; IGP, intragastric pressure; LI-LV, laminae I-V of the dorsal spinal horn; IMLN, intermediolateral nucleus; mRNA, messenger ribonucleic acid; NTS, nucleus tractus solitarii; Pa, Pascal; TRPV1, transient receptor potential ion channel of vanilloid type 1

Authors' contributions

Transcription (acid) of NTS in dorsal associated with urological neuroanatomy, spinal cord and asic
5) Confidence 0.54 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0.10 Pain Relevance 0.10
In contrast, and consistent with previous reports, levels of neurotensin and enkephalin mRNAs were upregulated on the lesioned side of the striatum.
Transcription (levels) of neurotensin in striatum associated with enkephalin
6) Confidence 0.52 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.77
A 6-hydroxydopamine lesion of the mesostriatal dopamine system decreases the expression of corticotropin releasing hormone and neurotensin mRNAs in the amygdala and bed nucleus of the stria terminalis.
Transcription (expression) of neurotensin in amygdala associated with dopamine, enkephalin and amygdala
7) Confidence 0.52 Published 2002 Journal Brain Res. Section Title Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.53
Levels of CRH and neurotensin mRNAs were decreased on the lesioned side in the CEA and oval nucleus of the BST (BSTov) relative to the intact side and to unoperated controls.
Transcription (Levels) of neurotensin in oval nucleus associated with amygdala
8) Confidence 0.52 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.67
The antisense blockade of c-fos reduced the effect of caffeine on the expression of mRNAs for preprotachykinin A and neurotensin/neuromedin N in the ventrolateral caudate-putamen.
Transcription (expression) of neurotensin/neuromedin N in caudate-putamen
9) Confidence 0.52 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9421173 Disease Relevance 0 Pain Relevance 0
Chronic pain increases brainstem proneurotensin/neuromedin-N mRNA expression: a hybridization-histochemical and immunohistochemical study using three different rat models for chronic nociception.
Transcription (expression) of neuromedin-N in brainstem associated with nociception, medulla and lasting pain
10) Confidence 0.52 Published 1993 Journal Brain Res. Section Title Doc Link 8518953 Disease Relevance 1.05 Pain Relevance 0.88
Chronic pain increases brainstem proneurotensin/neuromedin-N mRNA expression: a hybridization-histochemical and immunohistochemical study using three different rat models for chronic nociception.
Transcription (expression) of neurotensin in brainstem associated with nociception, medulla and lasting pain
11) Confidence 0.52 Published 1993 Journal Brain Res. Section Title Doc Link 8518953 Disease Relevance 1.05 Pain Relevance 0.89
A clear upregulation of neurotensin mRNA was seen after ether and, to a lesser extent, after immobilization stress, whereas after the two other stressors neurotensin mRNA was undetectable, as in control rats.
Transcription (undetectable) of neurotensin associated with stress
12) Confidence 0.52 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8337918 Disease Relevance 0.29 Pain Relevance 0.24
Additionally, there are concomitant increases in cellular levels of both neurotensin/neuromedin N and proenkephalin mRNAs.
Transcription (levels) of neurotensin/neuromedin N
13) Confidence 0.52 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721997 Disease Relevance 0.08 Pain Relevance 0.04
This study also suggests that a subpopulation of striatal neurons begin to express proneurotensin mRNA in response to haloperidol treatment.
Transcription (express) of neurotensin in neurons
14) Confidence 0.52 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2163009 Disease Relevance 0.08 Pain Relevance 0.46
Striatal DA depletion also induced significant increases (2.86-fold) in Nts mRNA levels (Figure 3D).
Transcription (levels) of Nts associated with dopamine
15) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.19
This study also evaluated the effects of aging and alcohol on the level of the mRNA encoding the common precursor of neurotensin (NT) and neuromedin N (NN).
Transcription (level) of neurotensin associated with aging and alcohol
16) Confidence 0.47 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9726289 Disease Relevance 0.44 Pain Relevance 0.21
Treatments were performed in defined insulin-free medium between days 6 and 8 of culture, since the maximal effects of NTs on somatostatin content and mRNA expression were observed after 48-h incubations.
Transcription (observed) of NTs associated with somatostatin
17) Confidence 0.37 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.65
Relative to the distribution of serotonin, somatostatin, peptide histidine isoleucine (PHI), methionine enkephalin, substance P and neurotensin-containing neuronal perikarya in the PAG, neurons containing immunoreactive pYT 22 occupied a unique location in the ventrolateral PAG.
Transcription (distribution) of neurotensin in neurons associated with somatostatin, enkephalin, central grey, serotonin and substance p
18) Confidence 0.29 Published 1988 Journal Brain Res. Section Abstract Doc Link 3147123 Disease Relevance 0.66 Pain Relevance 0.72
Since little is known about their action on gene expression in the adult hypothalamus, we examined the effects of these chemicals on the expression of estrogen-regulated mRNAs, i.e., progesterone receptor (PR) mRNA, preproenkephalin (PPE) mRNA and neurotensin (NT) mRNA, in the hypothalamus and pituitary of adult female rats.
Transcription (expression) of neurotensin in hypothalamus
19) Confidence 0.24 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
No differences between HR and LR in mRNA levels for dynorphin (DYN), preproenkephalin (PPE), glutamic acid decarboxylase (GAD) or neurotensin (NT) were observed in the core of the NACC.
Transcription (levels) of neurotensin in NACC associated with nucleus accumbens, dynorphin and generalized anxiety disorder
20) Confidence 0.20 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874516 Disease Relevance 0.56 Pain Relevance 0.55

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