INT2105

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Context Info
Confidence 0.41
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.90
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 2
heart valve 1
neurons 1
Rhd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 9 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
Opioid 6 99.52 Very High Very High Very High
Somatostatin 1 99.40 Very High Very High Very High
Morphine 9 99.28 Very High Very High Very High
Serotonin 1 99.28 Very High Very High Very High
palliative 3 99.06 Very High Very High Very High
narcan 8 98.24 Very High Very High Very High
substance P 8 97.44 Very High Very High Very High
Spinal cord 4 92.16 High High
Disease Link Frequency Relevance Heat
Rheumatic Heart Disease 31 100.00 Very High Very High Very High
Rheumatic Fever 17 100.00 Very High Very High Very High
Reprotox - General 1 37 98.84 Very High Very High Very High
Disease 36 93.24 High High
Coronary Artery Disease 2 88.28 High High
Pharyngitis 1 87.20 High High
Heart Disease 1 86.76 High High
Aortic Valve Insufficiency 2 86.28 High High
Chorea 1 84.80 Quite High
Myocarditis 1 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In view of recent evidence for presynaptic feedback inhibitory effects operating on opioid neurons, it is suggested that, following chronic exposure to morphine, the opioid neurons which normally inhibit LH-RH neurons are inhibited; upon treatment with naloxone, they are disinhibited and release more opioid peptides which then act to switch off LH-RH neuronal activity.
Negative_regulation (inhibit) of LH-RH in neurons associated with narcan, opioid and morphine
1) Confidence 0.41 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.42
In a second group of pentobarbital-anesthetized proestrous rats a significant decline in MBH-LH-RH occurred (to 573 +/- 137 pg/mg) which then remained at low concentrations between 14.00 h and 18.00 h proestrus.
Negative_regulation (decline) of LH-RH
2) Confidence 0.33 Published 1978 Journal Brain Res. Section Abstract Doc Link 350353 Disease Relevance 0.07 Pain Relevance 0.06
Prevention of RHD starts with school prophylaxis.
Negative_regulation (Prevention) of RHD associated with rheumatic heart disease
3) Confidence 0.26 Published 1999 Journal J Indian Med Assoc Section Abstract Doc Link 10643189 Disease Relevance 0.96 Pain Relevance 0
Once the heart valve is damaged any treatment is palliative, hence all efforts should be directed towards prevention of RHD.
Negative_regulation (prevention) of RHD in heart valve associated with rheumatic heart disease and palliative
4) Confidence 0.26 Published 1999 Journal J Indian Med Assoc Section Abstract Doc Link 10643189 Disease Relevance 0.89 Pain Relevance 0.10
However 10(-5)--10(-5) M synthetic enkephalin analogue induced a dose-dependent inhibition of LH-RH content and release of the mediobasal hypothalamus, which was prevented by equimolar concentrations of naloxone.
Negative_regulation (inhibition) of LH-RH in hypothalamus associated with narcan and enkephalin
5) Confidence 0.16 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 379712 Disease Relevance 0 Pain Relevance 0.30
However 10(-5)--10(-5) M synthetic enkephalin analogue induced a dose-dependent inhibition of LH-RH content and release of the mediobasal hypothalamus, which was prevented by equimolar concentrations of naloxone.
Negative_regulation (inhibition) of LH-RH in hypothalamus associated with narcan and enkephalin
6) Confidence 0.12 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 379712 Disease Relevance 0 Pain Relevance 0.30
Establishment of a coordinated control program for all regions of Australia where there are populations with high prevalence of ARF and RHD.
Negative_regulation (prevalence) of RHD associated with rheumatic fever and rheumatic heart disease
7) Confidence 0.08 Published 2007 Journal Med. J. Aust. Section Abstract Doc Link 17547548 Disease Relevance 1.25 Pain Relevance 0.16
Studies are needed on the lines of WHO recommendations for the regional prevalence of RF/RHD in school children throughout the country to detect regional variations.
Negative_regulation (prevalence) of RHD associated with rheumatic fever and rheumatic heart disease
8) Confidence 0.07 Published 1995 Journal Indian Heart J Section Abstract Doc Link 8557287 Disease Relevance 1.43 Pain Relevance 0.09
In contrast, various amino acids and serotonin (250 microM) produced little or no inhibition of [3H]MeTRH binding, and cholecystokinin, Leu- and Met-enkephalins, angiotensin II, LH-RH, bombesin and somatostatin were also markedly less potent than SP.
Negative_regulation (inhibition) of LH-RH associated with somatostatin, enkephalin, cholecystokinin, serotonin and substance p
9) Confidence 0.03 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6200806 Disease Relevance 0 Pain Relevance 0.86
Like for radiation therapy, the neoadjuvant or adjuvant use of hormone manipulation has not been completely evaluated, apart from an experience of Ficarra[19] who proposed a 3-year hormonal therapy with LH-RH blockade in the setting of high risk prostate cancer according to D'Amico risk classification, or the experimental findings of Paparel[37] with the use in a rat model of the synergic positive effects of HIFU and docetaxel.
Negative_regulation (blockade) of LH-RH associated with reprotox - general 1
10) Confidence 0.01 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878418 Disease Relevance 0.29 Pain Relevance 0.09

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