INT210506

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.76
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (TEP1) RNA binding (TEP1) nucleus (TEP1)
cytoplasm (TEP1)
Anatomy Link Frequency
hepatocytes 2
TEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 39 85.04 High High
cytokine 29 16.24 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Hepatitis 6 99.68 Very High Very High Very High
Hepatitis 38 98.64 Very High Very High Very High
Targeted Disruption 4 97.64 Very High Very High Very High
Aging 107 93.44 High High
Death 17 89.56 High High
INFLAMMATION 45 85.04 High High
Stress 20 84.84 Quite High
Necrosis 1 76.64 Quite High
Cancer 26 76.28 Quite High
Chromosomal Instability 2 66.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent publication described absence of telomerase activation following partial hepatectomy in hepatitis B virus X gene transgenic mice [39].
Negative_regulation (absence) of Positive_regulation (activation) of telomerase associated with targeted disruption and hepatitis
1) Confidence 0.28 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.64 Pain Relevance 0.04
Recent studies suggest that permissiveness of hepatocytes for telomerase activation might be impaired during chronic hepatitis.
Negative_regulation (impaired) of Positive_regulation (activation) of telomerase in hepatocytes associated with chronic hepatitis
2) Confidence 0.27 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.62 Pain Relevance 0.04
This diminution of CD28 signaling can contribute to the decrease of telomerase up-regulation as well as to decreased IL-2 production, leading to decreased or delayed proliferation (Kaltoft 1998).
Negative_regulation (decrease) of Positive_regulation (up-regulation) of telomerase
3) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.51 Pain Relevance 0

General Comments

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